Product Information
ISOTRETINOIN 30 MG CAPSULE is a generic product labeled by Upsher-Smith Laboratories LLC, priced at $4.4724 per EA under NDC 00245057301. Its NADAC has been published 208 times since Feb 9, 2022.
FDA first approved this application on Sep 21, 2021. Its Orange Book therapeutic-equivalence code is AB2 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
30 mg/1
Manufacturer
Upsher-Smith Laboratories LLCNDC
00245057301
Classification
Generic
Dosage Form
CAPSULE, LIQUID FILLED
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
ISOTRETINOINApproval Type
Generic (ANDA)
FDA Application
ANDA212333FDA Approved
9/21/2021
TE Code
AB2
On Market Since
9/21/2021
Pharmacological Classes
Price Statistics
The NADAC for ISOTRETINOIN 30 MG CAPSULE has been published 208 times since Feb 9, 2022, and over the history we have for it it has declined 83.2%. The table below summarizes its recorded NADAC range and movement.
| Current price | $4.4724 per EA |
|---|---|
| All-time high | $26.6923 (Jun 15, 2022) |
| All-time low | $3.6838 (Aug 19, 2026) |
| 52-week high | $10.7129 |
| 52-week low | $3.6838 |
| Median price | $14.9729 |
| Average price | $14.0429 |
| Largest weekly change | -37.4% (Feb 22, 2023) |
| Weeks tracked | 208 |
| Tracking since | Feb 9, 2022 |
Generic Alternatives
The matcher finds 7 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 52% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Upsher-Smith Laboratories LLC manufacturer profile
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Drug market
Isotretinoin market comparison
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Therapeutic class
Retinoid class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of ISOTRETINOIN 30 MG CAPSULE?
The current National Average Drug Acquisition Cost (NADAC) for ISOTRETINOIN 30 MG CAPSULE, manufactured by Upsher-Smith Laboratories LLC, is $4.4724 per EA (NDC 00245057301), effective Sep 30, 2026.
How has the price of ISOTRETINOIN 30 MG CAPSULE changed over time?
Over the history we have for it, the NADAC for ISOTRETINOIN 30 MG CAPSULE has declined 83.2%. It has been tracked across 208 weekly CMS publications since Feb 9, 2022.
What are the highest and lowest recorded NADAC prices for ISOTRETINOIN 30 MG CAPSULE?
Since Feb 9, 2022, the NADAC for ISOTRETINOIN 30 MG CAPSULE has ranged from a low of $3.6838 (Aug 19, 2026) to a high of $26.6923 (Jun 15, 2022), with a median of $14.9729 per EA.
Are there cheaper alternatives to ISOTRETINOIN 30 MG CAPSULE?
Yes. 7 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, ISOTRETINOIN 30 MG CAPSULE, is $2.1254 per EA — about 52% below ISOTRETINOIN 30 MG CAPSULE.
Who manufactures ISOTRETINOIN 30 MG CAPSULE?
ISOTRETINOIN 30 MG CAPSULE (NDC 00245057301) is labeled by Upsher-Smith Laboratories LLC, and CMS classifies it as a generic product.