Product Information
DIFFERIN 0.1% CREAM is a brand product labeled by Galderma Laboratories, L.P., priced at $11.2706 per GM under NDC 00299591545. Its NADAC has been published 505 times since Nov 28, 2013.
FDA first approved this application on May 26, 2000. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
1 mg/g
Manufacturer
Galderma Laboratories, L.P.NDC
00299591545
Classification
Brand
Dosage Form
CREAM
Route
TOPICAL
Effective Date
5/21/2025
Active Ingredients
ADAPALENEApproval Type
New Drug (NDA)
FDA Application
NDA020748FDA Approved
5/26/2000
TE Code
AB
On Market Since
11/24/2009
Pharmacological Classes
Price Statistics
The NADAC for DIFFERIN 0.1% CREAM has been published 505 times since Nov 28, 2013, and over the history we have for it it has risen 37.1%. The table below summarizes its recorded NADAC range and movement.
| Current price | $11.2706 per GM |
|---|---|
| All-time high | $11.5679 (Oct 12, 2016) |
| All-time low | $8.0864 (May 21, 2014) |
| 52-week high | $11.2706 |
| 52-week low | $11.2706 |
| Median price | $11.2572 |
| Average price | $10.7832 |
| Largest weekly change | +10.0% (Jul 8, 2015) |
| Weeks tracked | 505 |
| Tracking since | Nov 28, 2013 |
1W
N/A
1M
N/A
3M
N/A
6M
0.0%
1Y
0.0%
3Y
+0.4%
5Y
+0.0%
All
+37.1%
Last surveyed May 13, 2026 — this NDC no longer appears in the current weekly NADAC file.
Generic Alternatives
No other NADAC-published product shares this drug's active ingredient and strength in a comparable dosage form. Compare the broader picture on the Adapalene market page.
Lowest-Cost Alternatives
No alternatives available
Related Drugs
Same classification
Continue researching this drug
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Manufacturer
Galderma Laboratories, L.P. manufacturer profile
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Drug market
Adapalene market comparison
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Therapeutic class
Retinoid class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
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Frequently asked questions
What is the NADAC price of DIFFERIN 0.1% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for DIFFERIN 0.1% CREAM, manufactured by Galderma Laboratories, L.P., is $11.2706 per GM (NDC 00299591545), effective May 13, 2026.
How has the price of DIFFERIN 0.1% CREAM changed over time?
Over the history we have for it, the NADAC for DIFFERIN 0.1% CREAM has risen 37.1%. It has been tracked across 505 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for DIFFERIN 0.1% CREAM?
Since Nov 28, 2013, the NADAC for DIFFERIN 0.1% CREAM has ranged from a low of $8.0864 (May 21, 2014) to a high of $11.5679 (Oct 12, 2016), with a median of $11.2572 per GM.
Are there cheaper alternatives to DIFFERIN 0.1% CREAM?
No other NADAC-published product currently shares the active ingredient and strength of DIFFERIN 0.1% CREAM in a comparable dosage form, so no direct lower-cost alternative is listed.
Who manufactures DIFFERIN 0.1% CREAM?
DIFFERIN 0.1% CREAM (NDC 00299591545) is labeled by Galderma Laboratories, L.P., and CMS classifies it as a brand product.