Product Information
DIFFERIN 0.1% CREAM is a brand product labeled by Galderma Laboratories, L.P., priced at $11.2706 per GM under NDC 00299591545. Its NADAC has been published 505 times since Nov 28, 2013.
The High Outlier badge above means this manufacturer's average price in the Adapalene market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
Strength
1 mg/g
Manufacturer
Galderma Laboratories, L.P.NDC
00299591545
Classification
Brand
Dosage Form
CREAM
Route
TOPICAL
Last Updated
5/21/2025
Active Ingredients
ADAPALENEApproval Type
New Drug (NDA)
FDA Application
NDA020748On Market Since
11/24/2009
Pharmacological Classes
Price Statistics
The NADAC for DIFFERIN 0.1% CREAM has been published 505 times since Nov 28, 2013, and over the history we have for it it has risen 37.1%. The table below summarizes its recorded NADAC range and movement.
| Current price | $11.2706 per GM |
|---|---|
| All-time high | $11.5679 (Oct 12, 2016) |
| All-time low | $8.0864 (May 21, 2014) |
| 52-week high | $11.2706 |
| 52-week low | $11.2706 |
| Median price | $11.2572 |
| Average price | $10.7832 |
| Largest weekly change | +10.0% (Jul 8, 2015) |
| Weeks tracked | 505 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
The matcher finds 3 NADAC-published products sharing this drug's active ingredient, strength, and dosage form across 3 manufacturers (up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 97% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Frequently asked questions
What is the NADAC price of DIFFERIN 0.1% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for DIFFERIN 0.1% CREAM, manufactured by Galderma Laboratories, L.P., is $11.2706 per GM (NDC 00299591545), effective May 13, 2026.
How has the price of DIFFERIN 0.1% CREAM changed over time?
Over the history we have for it, the NADAC for DIFFERIN 0.1% CREAM has risen 37.1%. It has been tracked across 505 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for DIFFERIN 0.1% CREAM?
Since Nov 28, 2013, the NADAC for DIFFERIN 0.1% CREAM has ranged from a low of $8.0864 (May 21, 2014) to a high of $11.5679 (Oct 12, 2016), with a median of $11.2572 per GM.
Are there cheaper alternatives to DIFFERIN 0.1% CREAM?
Yes. 3 NADAC-published products share the same active ingredient, strength, and dosage form. The lowest-priced option, ADAPALENE 0.1% GEL, is $0.3402 per GM — about 97% below DIFFERIN 0.1% CREAM.
Who manufactures DIFFERIN 0.1% CREAM?
DIFFERIN 0.1% CREAM (NDC 00299591545) is labeled by Galderma Laboratories, L.P., and CMS classifies it as a brand product.
Related Drugs
Same classification