Adapalene
18 NDCs across 9 manufacturers|14 Generic,4 Brand
Adapalene is used to treat acne vulgaris, per the National Library of Medicine's MED-RT classification.
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The brand product was first FDA-approved on May 31, 1996, and the first generic was approved Jun 2, 2010. FDA's Orange Book lists 9 AB-rated (therapeutically equivalent) products for this ingredient. In 2024, Medicare Part D spent $3 million on Adapalene across 9,748 claims for 4,715 beneficiaries.
Adapalene is available as 18 NDCs from 9 manufacturers (14 generic, 4 brand), with NADAC prices from $0.34 to $11.63 per GM — the most expensive product costs about 35× the cheapest. Every pack size and labeler in this drug market is compared side-by-side below.
Total NDCs
18
14G / 4B
Manufacturers
9
competing in market
Price Spread
$0.34 – $11.63
per GM
7d Activity
avg +3.1% WoW · of 18 NDCs
Market Price Trend
Monthly average NADAC per unit, split by generic and brand.
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Top supplier
Galderma Laboratories, L.P. manufacturer profile
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Lead class
Retinoid class view
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Trend hub
Latest market trends
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Guide
How to interpret NADAC
Review the benchmark methodology behind the prices and spreads shown on this market page.
Manufacturer Breakdown
9 manufacturers producing ADAPALENE
| Drug ↕ | Price | 7d Change ↕ |
|---|---|---|
DIFFERIN 0.3% GEL PUMP | $11.6331 per GM | — |
DIFFERIN 0.1% CREAM | $11.2706 per GM | — |
ADAPALENE 0.1% CREAM | $2.8545 per GM | +14.63% |
ADAPALENE 0.1% CREAM | $2.8545 per GM | +14.63% |
ADAPALENE 0.3% GEL PUMP | $0.8502 per GM | +8.71% |
ADAPALENE 0.3% GEL PUMP | $0.8502 per GM | +8.71% |
ADAPALENE 0.3% GEL PUMP | $0.7822 per GM | — |
DIFFERIN 0.1% GEL | $0.7045 per GM | — |
ADAPALENE 0.3% GEL | $0.5038 per GM | -1.11% |
ADAPALENE 0.3% GEL | $0.5038 per GM | -1.11% |
ADAPALENE 0.3% GEL | $0.5038 per GM | -1.11% |
ADAPALENE 0.3% GEL | $0.5038 per GM | -1.11% |
ADAPALENE 0.1% GEL | $0.4655 per GM | -0.32% |
GNP ADAPALENE 0.1% GEL | $0.4655 per GM | -0.32% |
ADAPALENE 0.1% GEL | $0.4655 per GM | -0.32% |
DIFFERIN 0.1% GEL | $0.4639 per GM | — |
ADAPALENE 0.1% GEL | $0.3365 per GM | -0.45% |
ADAPALENE 0.1% GEL | $0.3365 per GM | -0.45% |
Frequently Asked Questions
What is Adapalene used to treat?
Adapalene is used to treat acne vulgaris, per the National Library of Medicine's MED-RT classification.
When did Adapalene become available as a generic?
FDA approved the first generic Adapalene (ANDA) on Jun 2, 2010. The Orange Book currently lists 9 AB-rated products for this ingredient, meaning FDA considers them therapeutically equivalent to the brand.
How much does Medicare spend on Adapalene?
In 2024, Medicare Part D spent $3 million on Adapalene across 9,748 claims for 4,715 beneficiaries.
How many Adapalene products are on the market?
The Adapalene drug market contains 18 NDCs from 9 manufacturers — 14 generic and 4 brand products.
What is the price range for Adapalene?
NADAC reference prices for Adapalene range from $0.3365 to $11.6331 per GM — the most expensive product costs about 35× the cheapest.
Is generic Adapalene cheaper than brand?
The average generic NADAC for Adapalene is $0.8769 per GM, versus $6.0180 for brand-labeled products — brand versions average about 6.9× the generic price.
Which manufacturers make Adapalene?
9 manufacturers list Adapalene in NADAC. Ranked by number of NDCs, the largest are Galderma Laboratories, L.P. (4), Sun Pharmaceutical Industries Inc. (4), Mayne Pharma (2), Alembic Pharmaceuticals Inc. (2), Rugby Laboratories (2).
How has the price of Adapalene changed recently?
Over the past 7 days, 4 Adapalene NDCs rose and 9 fell, with a market-wide average change of +3.1%.