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Product Information

RETIN-A 0.05% CREAM is a brand product labeled by Bausch Health US LLC, priced at $0.7904 per GM under NDC 00187516245. Its NADAC has been published 437 times since Aug 20, 2014.

FDA first approved this application before 1982. Its Orange Book therapeutic-equivalence code is AB1 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.

RETIN-A 0.05% CREAM

Tretinoin
$0.7904per GM

Strength

.5 mg/g

NDC

00187516245

Classification

Brand

Dosage Form

CREAM

Route

TOPICAL

Effective Date

7/28/2025

Active Ingredients

TRETINOIN

Approval Type

New Drug (NDA)

FDA Application

NDA017522

FDA Approved

Before 1982

TE Code

AB1

On Market Since

7/30/1974

Pharmacological Classes

Retinoid
Retinoids

Price Statistics

The NADAC for RETIN-A 0.05% CREAM has been published 437 times since Aug 20, 2014, and over the history we have for it it has declined 85.5%. The table below summarizes its recorded NADAC range and movement.

Current price$0.7904 per GM
All-time high$5.9234 (Oct 11, 2017)
All-time low$0.7192 (Feb 22, 2023)
52-week high$0.7904
52-week low$0.7904
Median price$1.6856
Average price$2.2914
Largest weekly change-65.7% (Mar 13, 2019)
Weeks tracked437
Tracking sinceAug 20, 2014

Price History

1W

N/A

1M

N/A

3M

N/A

6M

N/A

1Y

0.0%

3Y

+9.9%

5Y

-53.1%

All

-85.5%

Last surveyed Oct 1, 2025 — this NDC no longer appears in the current weekly NADAC file.

Generic Alternatives

The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.

Lowest-Cost Alternatives

2 alternatives • Same active ingredient

RETIN-A 0.05% CREAM
Brand
00187516220•Bausch Health US LLC
$0.7914
+0% more
TRETINOIN 0.05% CREAM
Generic
00378808345•Mylan Pharmaceuticals Inc.
$0.9284
+17% more

Related Drugs

Same classification

DIFFERIN 0.1% GEL
Brand
00299491045•Galderma Laboratories, L.P.
$0.4639
per GM
DIFFERIN 0.1% GEL
Brand
00299491015•Galderma Laboratories, L.P.
$0.7045
per GM
ALTRENO 0.05% LOTION
Brand
00187000520•Bausch Health US LLC
$2.3934
per GM
ALTRENO 0.05% LOTION
Brand
00187000545•Bausch Health US LLC
$2.4494
per GM
EPIDUO 0.1-2.5% GEL
Brand
00299590845•Galderma Laboratories, L.P.
$7.4842
per GM
TRI-LUMA CREAM
Brand
00299595030•Galderma Laboratories, L.P.
$7.8327
per GM
EPIDUO 0.1-2.5% GEL PUMP
Brand
00299590825•Galderma Laboratories, L.P.
$8.7729
per GM
DUOBRII 0.01%-0.045% LOTION
Brand
00187065301•Bausch Health US LLC
$10.0097
per GM
DIFFERIN 0.1% CREAM
Brand
00299591545•Galderma Laboratories, L.P.
$11.2706
per GM
ZIANA GEL
Brand
99207030060•Bausch Health US LLC
$11.4072
per GM

Frequently asked questions

What is the NADAC price of RETIN-A 0.05% CREAM?

The current National Average Drug Acquisition Cost (NADAC) for RETIN-A 0.05% CREAM, manufactured by Bausch Health US LLC, is $0.7904 per GM (NDC 00187516245), effective Oct 1, 2025.

How has the price of RETIN-A 0.05% CREAM changed over time?

Over the history we have for it, the NADAC for RETIN-A 0.05% CREAM has declined 85.5%. It has been tracked across 437 weekly CMS publications since Aug 20, 2014.

What are the highest and lowest recorded NADAC prices for RETIN-A 0.05% CREAM?

Since Aug 20, 2014, the NADAC for RETIN-A 0.05% CREAM has ranged from a low of $0.7192 (Feb 22, 2023) to a high of $5.9234 (Oct 11, 2017), with a median of $1.6856 per GM.

Are there cheaper alternatives to RETIN-A 0.05% CREAM?

2 manufacturers publish a NADAC-priced product with the same active ingredient and strength as RETIN-A 0.05% CREAM in a comparable dosage form, but none are currently priced below it.

Who manufactures RETIN-A 0.05% CREAM?

RETIN-A 0.05% CREAM (NDC 00187516245) is labeled by Bausch Health US LLC, and CMS classifies it as a brand product.