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Product Information

TWYNEO 0.1%-3% CREAM PUMP is a brand product labeled by Galderma Laboratories, L.P., priced at $31.6568 per GM under NDC 00299594530. Its NADAC has been published 48 times since Nov 23, 2022.

FDA first approved this application on Jul 26, 2021.

TWYNEO 0.1%-3% CREAM PUMP

tretinoin and benzoyl peroxide
$31.6568per GM

Strength

30; 1 mg/g; mg/g

NDC

00299594530

Classification

Brand

Dosage Form

CREAM

Route

TOPICAL

Effective Date

8/1/2026

Active Ingredients

BENZOYL PEROXIDE; TRETINOIN

Approval Type

New Drug (NDA)

FDA Application

NDA214902

FDA Approved

7/26/2021

On Market Since

3/15/2022

Pharmacological Classes

Retinoid
Retinoids

Price Statistics

The NADAC for TWYNEO 0.1%-3% CREAM PUMP has been published 48 times since Nov 23, 2022, and over the history we have for it it has risen 133.5%. The table below summarizes its recorded NADAC range and movement.

Current price$31.6568 per GM
All-time high$31.6568 (Aug 19, 2026)
All-time low$13.5548 (Nov 23, 2022)
52-week high$31.6568
52-week low$15.6574
Median price$15.6591
Average price$20.9045
Largest weekly change+91.7% (Apr 22, 2026)
Weeks tracked48
Tracking sinceNov 23, 2022

Price History

1W

0.0%

1M

+5.0%

3M

+5.3%

6M

+102.2%

1Y

+102.2%

3Y

+133.5%

5Y

N/A

All

+133.5%

Generic Alternatives

No other NADAC-published product shares this drug's active ingredient and strength in a comparable dosage form. Compare the broader picture on the tretinoin and benzoyl peroxide market page.

Lowest-Cost Alternatives

No alternatives available

No alternatives found with the same active ingredient and strength in a comparable dosage form.

Related Drugs

Same classification

DIFFERIN 0.1% GEL
Brand
00299491045•Galderma Laboratories, L.P.
$0.4639
per GM
DIFFERIN 0.1% GEL
Brand
00299491015•Galderma Laboratories, L.P.
$0.7045
per GM
RETIN-A 0.05% CREAM
Brand
00187516245•Bausch Health US LLC
$0.7904
per GM
RETIN-A 0.025% CREAM
Brand
00187516045•Bausch Health US LLC
$0.7904
per GM
RETIN-A 0.025% CREAM
Brand
00187516020•Bausch Health US LLC
$0.7907
per GM
RETIN-A 0.05% CREAM
Brand
00187516220•Bausch Health US LLC
$0.7914
per GM
RETIN-A 0.01% GEL
Brand
00187517245•Bausch Health US LLC
$0.9570
per GM
RETIN-A 0.025% GEL
Brand
00187517045•Bausch Health US LLC
$0.9582
per GM
RETIN-A 0.025% GEL
Brand
00187517015•Bausch Health US LLC
$0.9592
per GM
RETIN-A 0.1% CREAM
Brand
00187516420•Bausch Health US LLC
$0.9594
per GM

Frequently asked questions

What is the NADAC price of TWYNEO 0.1%-3% CREAM PUMP?

The current National Average Drug Acquisition Cost (NADAC) for TWYNEO 0.1%-3% CREAM PUMP, manufactured by Galderma Laboratories, L.P., is $31.6568 per GM (NDC 00299594530), effective Aug 19, 2026.

How has the price of TWYNEO 0.1%-3% CREAM PUMP changed over time?

Over the history we have for it, the NADAC for TWYNEO 0.1%-3% CREAM PUMP has risen 133.5%. It has been tracked across 48 weekly CMS publications since Nov 23, 2022.

What are the highest and lowest recorded NADAC prices for TWYNEO 0.1%-3% CREAM PUMP?

Since Nov 23, 2022, the NADAC for TWYNEO 0.1%-3% CREAM PUMP has ranged from a low of $13.5548 (Nov 23, 2022) to a high of $31.6568 (Aug 19, 2026), with a median of $15.6591 per GM.

Are there cheaper alternatives to TWYNEO 0.1%-3% CREAM PUMP?

No other NADAC-published product currently shares the active ingredient and strength of TWYNEO 0.1%-3% CREAM PUMP in a comparable dosage form, so no direct lower-cost alternative is listed.

Who manufactures TWYNEO 0.1%-3% CREAM PUMP?

TWYNEO 0.1%-3% CREAM PUMP (NDC 00299594530) is labeled by Galderma Laboratories, L.P., and CMS classifies it as a brand product.