Product Information
ESTRADIOL 0.1 MG PATCH (2/WK) is a generic product labeled by Mylan Pharmaceuticals Inc., priced at $8.5681 per EA under NDC 00378462326. Its NADAC has been published 405 times since Jan 2, 2019.
FDA first approved this application on Aug 15, 2018. Its Orange Book therapeutic-equivalence code is AB3 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.1 mg/d
Manufacturer
Mylan Pharmaceuticals Inc.NDC
00378462326
Classification
Generic
Dosage Form
PATCH
Route
TRANSDERMAL
Effective Date
9/23/2026
Active Ingredients
ESTRADIOLApproval Type
Generic (ANDA)
FDA Application
ANDA206685FDA Approved
8/15/2018
TE Code
AB3
On Market Since
11/1/2018
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.1 MG PATCH (2/WK) has been published 405 times since Jan 2, 2019, and over the history we have for it it has risen 11.7%. The table below summarizes its recorded NADAC range and movement.
| Current price | $8.5681 per EA |
|---|---|
| All-time high | $9.5510 (Jan 12, 2022) |
| All-time low | $5.0152 (Nov 20, 2024) |
| 52-week high | $8.5681 |
| 52-week low | $6.7754 |
| Median price | $7.1242 |
| Average price | $7.2308 |
| Largest weekly change | -24.4% (Nov 20, 2024) |
| Weeks tracked | 405 |
| Tracking since | Jan 2, 2019 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Mylan Pharmaceuticals Inc. manufacturer profile
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Drug market
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Therapeutic class
Estrogen class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.1 MG PATCH (2/WK)?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.1 MG PATCH (2/WK), manufactured by Mylan Pharmaceuticals Inc., is $8.5681 per EA (NDC 00378462326), effective Sep 30, 2026.
How has the price of ESTRADIOL 0.1 MG PATCH (2/WK) changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.1 MG PATCH (2/WK) has risen 11.7%. It has been tracked across 405 weekly CMS publications since Jan 2, 2019.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.1 MG PATCH (2/WK)?
Since Jan 2, 2019, the NADAC for ESTRADIOL 0.1 MG PATCH (2/WK) has ranged from a low of $5.0152 (Nov 20, 2024) to a high of $9.5510 (Jan 12, 2022), with a median of $7.1242 per EA.
Are there cheaper alternatives to ESTRADIOL 0.1 MG PATCH (2/WK)?
2 manufacturers publish a NADAC-priced product with the same active ingredient and strength as ESTRADIOL 0.1 MG PATCH (2/WK) in a comparable dosage form, but none are currently priced below it.
Who manufactures ESTRADIOL 0.1 MG PATCH (2/WK)?
ESTRADIOL 0.1 MG PATCH (2/WK) (NDC 00378462326) is labeled by Mylan Pharmaceuticals Inc., and CMS classifies it as a generic product.