Product Information
BUPRENORPHINE-NALOXONE 2-0.5 MG SL FILM is a generic product labeled by Mylan Pharmaceuticals Inc., priced at $1.3855 per EA under NDC 00378876593. Its NADAC has been published 330 times since Jun 10, 2020.
FDA first approved this application on Apr 17, 2020. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
2; .5 mg/1; mg/1
Manufacturer
Mylan Pharmaceuticals Inc.NDC
00378876593
Classification
Generic
Dosage Form
FILM
Route
BUCCAL; SUBLINGUAL
Effective Date
9/23/2026
Active Ingredients
BUPRENORPHINE HYDROCHLORIDE; NALOXONE HYDROCHLORIDE DIHYDRATEApproval Type
Generic (ANDA)
FDA Application
ANDA211785FDA Approved
4/17/2020
TE Code
AB
On Market Since
4/17/2020
Pharmacological Classes
Price Statistics
The NADAC for BUPRENORPHINE-NALOXONE 2-0.5 MG SL FILM has been published 330 times since Jun 10, 2020, and over the history we have for it it has declined 48.7%. The table below summarizes its recorded NADAC range and movement.
| Current price | $1.3855 per EA |
|---|---|
| All-time high | $2.7563 (Aug 11, 2021) |
| All-time low | $1.2418 (Nov 20, 2024) |
| 52-week high | $1.9127 |
| 52-week low | $1.2800 |
| Median price | $2.2414 |
| Average price | $2.1228 |
| Largest weekly change | +46.9% (Aug 21, 2024) |
| Weeks tracked | 330 |
| Tracking since | Jun 10, 2020 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
Use these direct paths to move from a single NDC into the surrounding market, manufacturer, class, and trend context.
Manufacturer
Mylan Pharmaceuticals Inc. manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Buprenorphine and Naloxone market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Opioid Antagonist class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of BUPRENORPHINE-NALOXONE 2-0.5 MG SL FILM?
The current National Average Drug Acquisition Cost (NADAC) for BUPRENORPHINE-NALOXONE 2-0.5 MG SL FILM, manufactured by Mylan Pharmaceuticals Inc., is $1.3855 per EA (NDC 00378876593), effective Sep 30, 2026.
How has the price of BUPRENORPHINE-NALOXONE 2-0.5 MG SL FILM changed over time?
Over the history we have for it, the NADAC for BUPRENORPHINE-NALOXONE 2-0.5 MG SL FILM has declined 48.7%. It has been tracked across 330 weekly CMS publications since Jun 10, 2020.
What are the highest and lowest recorded NADAC prices for BUPRENORPHINE-NALOXONE 2-0.5 MG SL FILM?
Since Jun 10, 2020, the NADAC for BUPRENORPHINE-NALOXONE 2-0.5 MG SL FILM has ranged from a low of $1.2418 (Nov 20, 2024) to a high of $2.7563 (Aug 11, 2021), with a median of $2.2414 per EA.
Are there cheaper alternatives to BUPRENORPHINE-NALOXONE 2-0.5 MG SL FILM?
2 manufacturers publish a NADAC-priced product with the same active ingredient and strength as BUPRENORPHINE-NALOXONE 2-0.5 MG SL FILM in a comparable dosage form, but none are currently priced below it.
Who manufactures BUPRENORPHINE-NALOXONE 2-0.5 MG SL FILM?
BUPRENORPHINE-NALOXONE 2-0.5 MG SL FILM (NDC 00378876593) is labeled by Mylan Pharmaceuticals Inc., and CMS classifies it as a generic product.