Product Information
ESTRADIOL 0.01% CREAM is a generic product labeled by Mylan Pharmaceuticals Inc., priced at $0.4257 per GM under NDC 00378877035. Its NADAC has been published 440 times since Mar 21, 2018.
FDA first approved this application on Dec 29, 2017. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.1 mg/g
Manufacturer
Mylan Pharmaceuticals Inc.NDC
00378877035
Classification
Generic
Dosage Form
CREAM
Route
VAGINAL
Effective Date
8/19/2026
Active Ingredients
ESTRADIOLApproval Type
Generic (ANDA)
FDA Application
ANDA208788FDA Approved
12/29/2017
TE Code
AB
On Market Since
12/29/2017
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.01% CREAM has been published 440 times since Mar 21, 2018, and over the history we have for it it has declined 92.5%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.4257 per GM |
|---|---|
| All-time high | $5.6500 (Apr 11, 2018) |
| All-time low | $0.3692 (Nov 20, 2024) |
| 52-week high | $0.4871 |
| 52-week low | $0.3802 |
| Median price | $0.8189 |
| Average price | $1.5346 |
| Largest weekly change | -24.2% (Nov 20, 2024) |
| Weeks tracked | 440 |
| Tracking since | Mar 21, 2018 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.01% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.01% CREAM, manufactured by Mylan Pharmaceuticals Inc., is $0.4257 per GM (NDC 00378877035), effective Aug 19, 2026.
How has the price of ESTRADIOL 0.01% CREAM changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.01% CREAM has declined 92.5%. It has been tracked across 440 weekly CMS publications since Mar 21, 2018.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.01% CREAM?
Since Mar 21, 2018, the NADAC for ESTRADIOL 0.01% CREAM has ranged from a low of $0.3692 (Nov 20, 2024) to a high of $5.6500 (Apr 11, 2018), with a median of $0.8189 per GM.
Are there cheaper alternatives to ESTRADIOL 0.01% CREAM?
3 manufacturers publish a NADAC-priced product with the same active ingredient and strength as ESTRADIOL 0.01% CREAM in a comparable dosage form, but none are currently priced below it.
Who manufactures ESTRADIOL 0.01% CREAM?
ESTRADIOL 0.01% CREAM (NDC 00378877035) is labeled by Mylan Pharmaceuticals Inc., and CMS classifies it as a generic product.