Product Information
ESTRADIOL 0.01% CREAM is a generic product labeled by Mylan Pharmaceuticals Inc., priced at $0.3888 per GM under NDC 00378877035. Its NADAC has been published 432 times since Mar 21, 2018.
Strength
.1 mg/g
Manufacturer
Mylan Pharmaceuticals Inc.NDC
00378877035
Classification
Generic
Dosage Form
CREAM
Route
VAGINAL
Last Updated
6/17/2026
Active Ingredients
ESTRADIOLApproval Type
Generic (ANDA)
FDA Application
ANDA208788On Market Since
12/29/2017
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.01% CREAM has been published 432 times since Mar 21, 2018, and over the history we have for it it has declined 93.1%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.3888 per GM |
|---|---|
| All-time high | $5.6500 (Apr 11, 2018) |
| All-time low | $0.3692 (Nov 20, 2024) |
| 52-week high | $0.4871 |
| 52-week low | $0.3861 |
| Median price | $0.8447 |
| Average price | $1.5558 |
| Largest weekly change | -24.2% (Nov 20, 2024) |
| Weeks tracked | 432 |
| Tracking since | Mar 21, 2018 |
Generic Alternatives
The matcher finds 3 NADAC-published products sharing this drug's active ingredient, strength, and dosage form across 3 manufacturers (up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.01% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.01% CREAM, manufactured by Mylan Pharmaceuticals Inc., is $0.3888 per GM (NDC 00378877035), effective Jun 24, 2026.
How has the price of ESTRADIOL 0.01% CREAM changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.01% CREAM has declined 93.1%. It has been tracked across 432 weekly CMS publications since Mar 21, 2018.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.01% CREAM?
Since Mar 21, 2018, the NADAC for ESTRADIOL 0.01% CREAM has ranged from a low of $0.3692 (Nov 20, 2024) to a high of $5.6500 (Apr 11, 2018), with a median of $0.8447 per GM.
Are there cheaper alternatives to ESTRADIOL 0.01% CREAM?
3 NADAC-published products share the same active ingredient, strength, and dosage form as ESTRADIOL 0.01% CREAM, but none are currently priced below it.
Who manufactures ESTRADIOL 0.01% CREAM?
ESTRADIOL 0.01% CREAM (NDC 00378877035) is labeled by Mylan Pharmaceuticals Inc., and CMS classifies it as a generic product.
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Same classification