Product Information
ESTRADIOL 0.01% CREAM is a generic product labeled by Teva Pharmaceuticals USA Inc., priced at $0.4645 per GM under NDC 00093354143. Its NADAC has been published 446 times since Mar 21, 2018.
FDA first approved this application on Jan 31, 1984. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.1 mg/g
Manufacturer
Teva Pharmaceuticals USA Inc.NDC
00093354143
Classification
Generic
Dosage Form
CREAM
Route
VAGINAL
Effective Date
9/23/2026
Active Ingredients
ESTRADIOLApproval Type
Generic (ANDA)
FDA Application
ANDA086069FDA Approved
1/31/1984
TE Code
AB
On Market Since
1/2/2018
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.01% CREAM has been published 446 times since Mar 21, 2018, and over the history we have for it it has declined 91.8%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.4645 per GM |
|---|---|
| All-time high | $5.6500 (Apr 11, 2018) |
| All-time low | $0.3692 (Nov 20, 2024) |
| 52-week high | $0.4696 |
| 52-week low | $0.3802 |
| Median price | $0.7793 |
| Average price | $1.5199 |
| Largest weekly change | -24.2% (Nov 20, 2024) |
| Weeks tracked | 446 |
| Tracking since | Mar 21, 2018 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Teva Pharmaceuticals USA Inc. manufacturer profile
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Drug market
Estradiol market comparison
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Therapeutic class
Estrogen class view
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Trend hub
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.01% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.01% CREAM, manufactured by Teva Pharmaceuticals USA Inc., is $0.4645 per GM (NDC 00093354143), effective Sep 30, 2026.
How has the price of ESTRADIOL 0.01% CREAM changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.01% CREAM has declined 91.8%. It has been tracked across 446 weekly CMS publications since Mar 21, 2018.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.01% CREAM?
Since Mar 21, 2018, the NADAC for ESTRADIOL 0.01% CREAM has ranged from a low of $0.3692 (Nov 20, 2024) to a high of $5.6500 (Apr 11, 2018), with a median of $0.7793 per GM.
Are there cheaper alternatives to ESTRADIOL 0.01% CREAM?
3 manufacturers publish a NADAC-priced product with the same active ingredient and strength as ESTRADIOL 0.01% CREAM in a comparable dosage form, but none are currently priced below it.
Who manufactures ESTRADIOL 0.01% CREAM?
ESTRADIOL 0.01% CREAM (NDC 00093354143) is labeled by Teva Pharmaceuticals USA Inc., and CMS classifies it as a generic product.