Product Information
ESTRADIOL 0.01% CREAM is a generic product labeled by Alvogen Inc., priced at $0.4645 per GM under NDC 47781010444. Its NADAC has been published 424 times since Aug 22, 2018.
FDA first approved this application on Mar 5, 2018. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.1 mg/g
Manufacturer
Alvogen Inc.NDC
47781010444
Classification
Generic
Dosage Form
CREAM
Route
VAGINAL
Effective Date
9/23/2026
Active Ingredients
ESTRADIOL HEMIHYDRATEApproval Type
Generic (ANDA)
FDA Application
ANDA209767FDA Approved
3/5/2018
TE Code
AB
On Market Since
3/5/2018
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.01% CREAM has been published 424 times since Aug 22, 2018, and over the history we have for it it has declined 89.4%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.4645 per GM |
|---|---|
| All-time high | $4.3856 (Sep 12, 2018) |
| All-time low | $0.3692 (Nov 20, 2024) |
| 52-week high | $0.4696 |
| 52-week low | $0.3802 |
| Median price | $0.7509 |
| Average price | $1.3369 |
| Largest weekly change | -24.2% (Nov 20, 2024) |
| Weeks tracked | 424 |
| Tracking since | Aug 22, 2018 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Alvogen Inc. manufacturer profile
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Drug market
Estradiol market comparison
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Therapeutic class
Estrogen class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.01% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.01% CREAM, manufactured by Alvogen Inc., is $0.4645 per GM (NDC 47781010444), effective Sep 30, 2026.
How has the price of ESTRADIOL 0.01% CREAM changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.01% CREAM has declined 89.4%. It has been tracked across 424 weekly CMS publications since Aug 22, 2018.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.01% CREAM?
Since Aug 22, 2018, the NADAC for ESTRADIOL 0.01% CREAM has ranged from a low of $0.3692 (Nov 20, 2024) to a high of $4.3856 (Sep 12, 2018), with a median of $0.7509 per GM.
Are there cheaper alternatives to ESTRADIOL 0.01% CREAM?
3 manufacturers publish a NADAC-priced product with the same active ingredient and strength as ESTRADIOL 0.01% CREAM in a comparable dosage form, but none are currently priced below it.
Who manufactures ESTRADIOL 0.01% CREAM?
ESTRADIOL 0.01% CREAM (NDC 47781010444) is labeled by Alvogen Inc., and CMS classifies it as a generic product.