Product Information
ESTRADIOL 0.01% CREAM is a generic product labeled by Padagis Israel Pharmaceuticals Ltd, priced at $0.4257 per GM under NDC 45802009735. Its NADAC has been published 285 times since Mar 10, 2021.
FDA first approved this application on Jan 22, 2018. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.1 mg/g
Manufacturer
Padagis Israel Pharmaceuticals LtdNDC
45802009735
Classification
Generic
Dosage Form
CREAM
Route
VAGINAL
Effective Date
8/19/2026
Active Ingredients
ESTRADIOLApproval Type
Generic (ANDA)
FDA Application
ANDA210194FDA Approved
1/22/2018
TE Code
AB
On Market Since
1/6/2021
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.01% CREAM has been published 285 times since Mar 10, 2021, and over the history we have for it it has declined 72.8%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.4257 per GM |
|---|---|
| All-time high | $1.5922 (Apr 14, 2021) |
| All-time low | $0.3692 (Nov 20, 2024) |
| 52-week high | $0.4871 |
| 52-week low | $0.3802 |
| Median price | $0.5558 |
| Average price | $0.6994 |
| Largest weekly change | -24.2% (Nov 20, 2024) |
| Weeks tracked | 285 |
| Tracking since | Mar 10, 2021 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.01% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.01% CREAM, manufactured by Padagis Israel Pharmaceuticals Ltd, is $0.4257 per GM (NDC 45802009735), effective Aug 19, 2026.
How has the price of ESTRADIOL 0.01% CREAM changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.01% CREAM has declined 72.8%. It has been tracked across 285 weekly CMS publications since Mar 10, 2021.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.01% CREAM?
Since Mar 10, 2021, the NADAC for ESTRADIOL 0.01% CREAM has ranged from a low of $0.3692 (Nov 20, 2024) to a high of $1.5922 (Apr 14, 2021), with a median of $0.5558 per GM.
Are there cheaper alternatives to ESTRADIOL 0.01% CREAM?
3 manufacturers publish a NADAC-priced product with the same active ingredient and strength as ESTRADIOL 0.01% CREAM in a comparable dosage form, but none are currently priced below it.
Who manufactures ESTRADIOL 0.01% CREAM?
ESTRADIOL 0.01% CREAM (NDC 45802009735) is labeled by Padagis Israel Pharmaceuticals Ltd, and CMS classifies it as a generic product.