Product Information
NALOXONE 0.4 MG/ML VIAL is a generic product labeled by Hospira Inc., priced at $4.0147 per ML under NDC 00409121501. Its NADAC has been published 372 times since Dec 23, 2015.
FDA first approved this application on Jan 7, 1987. Its Orange Book therapeutic-equivalence code is AP.
Strength
.4 mg/mL
Manufacturer
Hospira Inc.NDC
00409121501
Classification
Generic
Dosage Form
INJECTION, SOLUTION
Route
INTRAMUSCULAR; INTRAVENOUS; SUBCUTANEOUS
Effective Date
8/19/2026
Active Ingredients
NALOXONE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA070256FDA Approved
1/7/1987
TE Code
AP
On Market Since
7/12/2005
Pharmacological Classes
Price Statistics
The NADAC for NALOXONE 0.4 MG/ML VIAL has been published 372 times since Dec 23, 2015, and over the history we have for it it has declined 73.3%. The table below summarizes its recorded NADAC range and movement.
| Current price | $4.0147 per ML |
|---|---|
| All-time high | $15.7839 (Aug 16, 2017) |
| All-time low | $3.8172 (Dec 17, 2025) |
| 52-week high | $5.3047 |
| 52-week low | $3.8172 |
| Median price | $11.2094 |
| Average price | $9.7873 |
| Largest weekly change | -42.1% (Jul 20, 2022) |
| Weeks tracked | 372 |
| Tracking since | Dec 23, 2015 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of NALOXONE 0.4 MG/ML VIAL?
The current National Average Drug Acquisition Cost (NADAC) for NALOXONE 0.4 MG/ML VIAL, manufactured by Hospira Inc., is $4.0147 per ML (NDC 00409121501), effective Aug 19, 2026.
How has the price of NALOXONE 0.4 MG/ML VIAL changed over time?
Over the history we have for it, the NADAC for NALOXONE 0.4 MG/ML VIAL has declined 73.3%. It has been tracked across 372 weekly CMS publications since Dec 23, 2015.
What are the highest and lowest recorded NADAC prices for NALOXONE 0.4 MG/ML VIAL?
Since Dec 23, 2015, the NADAC for NALOXONE 0.4 MG/ML VIAL has ranged from a low of $3.8172 (Dec 17, 2025) to a high of $15.7839 (Aug 16, 2017), with a median of $11.2094 per ML.
Are there cheaper alternatives to NALOXONE 0.4 MG/ML VIAL?
3 manufacturers publish a NADAC-priced product with the same active ingredient and strength as NALOXONE 0.4 MG/ML VIAL in a comparable dosage form, but none are currently priced below it.
Who manufactures NALOXONE 0.4 MG/ML VIAL?
NALOXONE 0.4 MG/ML VIAL (NDC 00409121501) is labeled by Hospira Inc., and CMS classifies it as a generic product.