Product Information
BUPRENORPHINE-NALOXONE 2-0.5 MG SL TABLET is a generic product labeled by Major Pharmaceuticals, priced at $0.5214 per EA under NDC 00904700906. Its NADAC has been published 285 times since Apr 21, 2021.
FDA first approved this application on Jun 27, 2014. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
BUPRENORPHINE-NALOXONE 2-0.5 MG SL TABLET
buprenorphine hydrochloride and naloxone hydrochloride dihydrateStrength
2; .5 mg/1; mg/1
Manufacturer
Major PharmaceuticalsNDC
00904700906
Classification
Generic
Dosage Form
TABLET
Route
SUBLINGUAL
Effective Date
9/23/2026
Active Ingredients
BUPRENORPHINE HYDROCHLORIDE; NALOXONE HYDROCHLORIDE DIHYDRATEApproval Type
Generic (ANDA)
FDA Application
ANDA203326FDA Approved
6/27/2014
TE Code
AB
On Market Since
6/27/2014
Pharmacological Classes
Price Statistics
The NADAC for BUPRENORPHINE-NALOXONE 2-0.5 MG SL TABLET has been published 285 times since Apr 21, 2021, and over the history we have for it it has declined 48.9%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.5214 per EA |
|---|---|
| All-time high | $1.0654 (Aug 11, 2021) |
| All-time low | $0.3740 (Nov 20, 2024) |
| 52-week high | $0.5224 |
| 52-week low | $0.4123 |
| Median price | $0.5889 |
| Average price | $0.6130 |
| Largest weekly change | +58.5% (Aug 21, 2024) |
| Weeks tracked | 285 |
| Tracking since | Apr 21, 2021 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Major Pharmaceuticals manufacturer profile
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Drug market
buprenorphine hydrochloride and naloxone hydrochloride dihydrate market comparison
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Therapeutic class
Opioid Antagonist class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of BUPRENORPHINE-NALOXONE 2-0.5 MG SL TABLET?
The current National Average Drug Acquisition Cost (NADAC) for BUPRENORPHINE-NALOXONE 2-0.5 MG SL TABLET, manufactured by Major Pharmaceuticals, is $0.5214 per EA (NDC 00904700906), effective Sep 30, 2026.
How has the price of BUPRENORPHINE-NALOXONE 2-0.5 MG SL TABLET changed over time?
Over the history we have for it, the NADAC for BUPRENORPHINE-NALOXONE 2-0.5 MG SL TABLET has declined 48.9%. It has been tracked across 285 weekly CMS publications since Apr 21, 2021.
What are the highest and lowest recorded NADAC prices for BUPRENORPHINE-NALOXONE 2-0.5 MG SL TABLET?
Since Apr 21, 2021, the NADAC for BUPRENORPHINE-NALOXONE 2-0.5 MG SL TABLET has ranged from a low of $0.3740 (Nov 20, 2024) to a high of $1.0654 (Aug 11, 2021), with a median of $0.5889 per EA.
Are there cheaper alternatives to BUPRENORPHINE-NALOXONE 2-0.5 MG SL TABLET?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as BUPRENORPHINE-NALOXONE 2-0.5 MG SL TABLET in a comparable dosage form, but none are currently priced below it.
Who manufactures BUPRENORPHINE-NALOXONE 2-0.5 MG SL TABLET?
BUPRENORPHINE-NALOXONE 2-0.5 MG SL TABLET (NDC 00904700906) is labeled by Major Pharmaceuticals, and CMS classifies it as a generic product.