Product Information
BUPRENORPHINE-NALOXONE 2-0.5 MG SL TABLET is a generic product labeled by Actavis Pharma, Inc., priced at $0.5214 per EA under NDC 00228315403. Its NADAC has been published 475 times since Nov 28, 2013.
FDA first approved this application on Feb 22, 2013. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
2; .5 mg/1; mg/1
Manufacturer
Actavis Pharma, Inc.NDC
00228315403
Classification
Generic
Dosage Form
TABLET
Route
SUBLINGUAL
Effective Date
9/23/2026
Active Ingredients
BUPRENORPHINE HYDROCHLORIDE; NALOXONE HYDROCHLORIDE DIHYDRATEApproval Type
Generic (ANDA)
FDA Application
ANDA091422FDA Approved
2/22/2013
TE Code
AB
On Market Since
3/4/2013
Pharmacological Classes
Price Statistics
The NADAC for BUPRENORPHINE-NALOXONE 2-0.5 MG SL TABLET has been published 475 times since Nov 28, 2013, and over the history we have for it it has declined 85.9%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.5214 per EA |
|---|---|
| All-time high | $3.7455 (Aug 13, 2014) |
| All-time low | $0.3740 (Nov 20, 2024) |
| 52-week high | $0.5224 |
| 52-week low | $0.4123 |
| Median price | $0.7522 |
| Average price | $1.5718 |
| Largest weekly change | -67.5% (Sep 9, 2020) |
| Weeks tracked | 475 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
The matcher finds 6 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Actavis Pharma, Inc. manufacturer profile
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Drug market
Buprenorphine and Naloxone market comparison
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Therapeutic class
Opioid Antagonist class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of BUPRENORPHINE-NALOXONE 2-0.5 MG SL TABLET?
The current National Average Drug Acquisition Cost (NADAC) for BUPRENORPHINE-NALOXONE 2-0.5 MG SL TABLET, manufactured by Actavis Pharma, Inc., is $0.5214 per EA (NDC 00228315403), effective Sep 30, 2026.
How has the price of BUPRENORPHINE-NALOXONE 2-0.5 MG SL TABLET changed over time?
Over the history we have for it, the NADAC for BUPRENORPHINE-NALOXONE 2-0.5 MG SL TABLET has declined 85.9%. It has been tracked across 475 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for BUPRENORPHINE-NALOXONE 2-0.5 MG SL TABLET?
Since Nov 28, 2013, the NADAC for BUPRENORPHINE-NALOXONE 2-0.5 MG SL TABLET has ranged from a low of $0.3740 (Nov 20, 2024) to a high of $3.7455 (Aug 13, 2014), with a median of $0.7522 per EA.
Are there cheaper alternatives to BUPRENORPHINE-NALOXONE 2-0.5 MG SL TABLET?
6 manufacturers publish a NADAC-priced product with the same active ingredient and strength as BUPRENORPHINE-NALOXONE 2-0.5 MG SL TABLET in a comparable dosage form, but none are currently priced below it.
Who manufactures BUPRENORPHINE-NALOXONE 2-0.5 MG SL TABLET?
BUPRENORPHINE-NALOXONE 2-0.5 MG SL TABLET (NDC 00228315403) is labeled by Actavis Pharma, Inc., and CMS classifies it as a generic product.