Product Information
LOTEPREDNOL ETABONATE 0.5% DRP is a generic product labeled by Padagis US LLC, priced at $10.5316 per ML under NDC 00574413505. Its NADAC has been published 29 times since Feb 4, 2026.
FDA first approved this application on Jan 29, 2025. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
5 mg/mL
Manufacturer
Padagis US LLCNDC
00574413505
Classification
Generic
Dosage Form
SUSPENSION/ DROPS
Route
OPHTHALMIC
Effective Date
8/19/2026
Active Ingredients
LOTEPREDNOL ETABONATEApproval Type
Generic (ANDA)
FDA Application
ANDA215204FDA Approved
1/29/2025
TE Code
AB
On Market Since
12/15/2025
Pharmacological Classes
Price Statistics
The NADAC for LOTEPREDNOL ETABONATE 0.5% DRP has been published 29 times since Feb 4, 2026, and over the history we have for it it has declined 39.7%. The table below summarizes its recorded NADAC range and movement.
| Current price | $10.5316 per ML |
|---|---|
| All-time high | $17.4624 (Feb 11, 2026) |
| All-time low | $10.1799 (Jul 22, 2026) |
| 52-week high | $17.4624 |
| 52-week low | $10.1799 |
| Median price | $11.3286 |
| Average price | $11.8729 |
| Largest weekly change | -19.6% (Feb 18, 2026) |
| Weeks tracked | 29 |
| Tracking since | Feb 4, 2026 |
Generic Alternatives
The matcher finds 5 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of LOTEPREDNOL ETABONATE 0.5% DRP?
The current National Average Drug Acquisition Cost (NADAC) for LOTEPREDNOL ETABONATE 0.5% DRP, manufactured by Padagis US LLC, is $10.5316 per ML (NDC 00574413505), effective Aug 19, 2026.
How has the price of LOTEPREDNOL ETABONATE 0.5% DRP changed over time?
Over the history we have for it, the NADAC for LOTEPREDNOL ETABONATE 0.5% DRP has declined 39.7%. It has been tracked across 29 weekly CMS publications since Feb 4, 2026.
What are the highest and lowest recorded NADAC prices for LOTEPREDNOL ETABONATE 0.5% DRP?
Since Feb 4, 2026, the NADAC for LOTEPREDNOL ETABONATE 0.5% DRP has ranged from a low of $10.1799 (Jul 22, 2026) to a high of $17.4624 (Feb 11, 2026), with a median of $11.3286 per ML.
Are there cheaper alternatives to LOTEPREDNOL ETABONATE 0.5% DRP?
5 manufacturers publish a NADAC-priced product with the same active ingredient and strength as LOTEPREDNOL ETABONATE 0.5% DRP in a comparable dosage form, but none are currently priced below it.
Who manufactures LOTEPREDNOL ETABONATE 0.5% DRP?
LOTEPREDNOL ETABONATE 0.5% DRP (NDC 00574413505) is labeled by Padagis US LLC, and CMS classifies it as a generic product.