Product Information
LOTEPREDNOL ETABONATE 0.5% DRP is a generic product labeled by Amneal Pharmaceuticals NY LLC, priced at $10.4737 per ML under NDC 60219136201. Its NADAC has been published 53 times since Oct 1, 2025.
FDA first approved this application on May 20, 2025. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
5 mg/mL
Manufacturer
Amneal Pharmaceuticals NY LLCNDC
60219136201
Classification
Generic
Dosage Form
SUSPENSION/ DROPS
Route
OPHTHALMIC
Effective Date
9/23/2026
Active Ingredients
LOTEPREDNOL ETABONATEApproval Type
Generic (ANDA)
FDA Application
ANDA217484FDA Approved
5/20/2025
TE Code
AB
On Market Since
5/22/2025
Pharmacological Classes
Price Statistics
The NADAC for LOTEPREDNOL ETABONATE 0.5% DRP has been published 53 times since Oct 1, 2025, and over the history we have for it it has declined 46.3%. The table below summarizes its recorded NADAC range and movement.
| Current price | $10.4737 per ML |
|---|---|
| All-time high | $20.1780 (Dec 10, 2025) |
| All-time low | $10.1799 (Jul 22, 2026) |
| 52-week high | $20.1780 |
| 52-week low | $10.1799 |
| Median price | $12.3302 |
| Average price | $14.3374 |
| Largest weekly change | -19.6% (Feb 18, 2026) |
| Weeks tracked | 53 |
| Tracking since | Oct 1, 2025 |
Generic Alternatives
The matcher finds 4 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Amneal Pharmaceuticals NY LLC manufacturer profile
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Drug market
loteprednol etabonate market comparison
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Therapeutic class
Corticosteroid class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of LOTEPREDNOL ETABONATE 0.5% DRP?
The current National Average Drug Acquisition Cost (NADAC) for LOTEPREDNOL ETABONATE 0.5% DRP, manufactured by Amneal Pharmaceuticals NY LLC, is $10.4737 per ML (NDC 60219136201), effective Sep 30, 2026.
How has the price of LOTEPREDNOL ETABONATE 0.5% DRP changed over time?
Over the history we have for it, the NADAC for LOTEPREDNOL ETABONATE 0.5% DRP has declined 46.3%. It has been tracked across 53 weekly CMS publications since Oct 1, 2025.
What are the highest and lowest recorded NADAC prices for LOTEPREDNOL ETABONATE 0.5% DRP?
Since Oct 1, 2025, the NADAC for LOTEPREDNOL ETABONATE 0.5% DRP has ranged from a low of $10.1799 (Jul 22, 2026) to a high of $20.1780 (Dec 10, 2025), with a median of $12.3302 per ML.
Are there cheaper alternatives to LOTEPREDNOL ETABONATE 0.5% DRP?
4 manufacturers publish a NADAC-priced product with the same active ingredient and strength as LOTEPREDNOL ETABONATE 0.5% DRP in a comparable dosage form, but none are currently priced below it.
Who manufactures LOTEPREDNOL ETABONATE 0.5% DRP?
LOTEPREDNOL ETABONATE 0.5% DRP (NDC 60219136201) is labeled by Amneal Pharmaceuticals NY LLC, and CMS classifies it as a generic product.