Product Information
LOTEPREDNOL ETABONATE 0.5% DRP is a generic product labeled by Padagis US LLC, priced at $17.5474 per ML under NDC 00574413515. Its NADAC has been published 29 times since Feb 4, 2026.
FDA first approved this application on Jan 29, 2025. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
5 mg/mL
Manufacturer
Padagis US LLCNDC
00574413515
Classification
Generic
Dosage Form
SUSPENSION/ DROPS
Route
OPHTHALMIC
Effective Date
8/19/2026
Active Ingredients
LOTEPREDNOL ETABONATEApproval Type
Generic (ANDA)
FDA Application
ANDA215204FDA Approved
1/29/2025
TE Code
AB
On Market Since
12/15/2025
Pharmacological Classes
Price Statistics
The NADAC for LOTEPREDNOL ETABONATE 0.5% DRP has been published 29 times since Feb 4, 2026, and over the history we have for it it has declined 7.3%. The table below summarizes its recorded NADAC range and movement.
| Current price | $17.5474 per ML |
|---|---|
| All-time high | $20.1315 (Apr 15, 2026) |
| All-time low | $17.5474 (Aug 19, 2026) |
| 52-week high | $20.1315 |
| 52-week low | $17.5474 |
| Median price | $18.9254 |
| Average price | $18.8746 |
| Largest weekly change | -4.6% (Apr 22, 2026) |
| Weeks tracked | 29 |
| Tracking since | Feb 4, 2026 |
Generic Alternatives
The matcher finds 5 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 40% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of LOTEPREDNOL ETABONATE 0.5% DRP?
The current National Average Drug Acquisition Cost (NADAC) for LOTEPREDNOL ETABONATE 0.5% DRP, manufactured by Padagis US LLC, is $17.5474 per ML (NDC 00574413515), effective Aug 19, 2026.
How has the price of LOTEPREDNOL ETABONATE 0.5% DRP changed over time?
Over the history we have for it, the NADAC for LOTEPREDNOL ETABONATE 0.5% DRP has declined 7.3%. It has been tracked across 29 weekly CMS publications since Feb 4, 2026.
What are the highest and lowest recorded NADAC prices for LOTEPREDNOL ETABONATE 0.5% DRP?
Since Feb 4, 2026, the NADAC for LOTEPREDNOL ETABONATE 0.5% DRP has ranged from a low of $17.5474 (Aug 19, 2026) to a high of $20.1315 (Apr 15, 2026), with a median of $18.9254 per ML.
Are there cheaper alternatives to LOTEPREDNOL ETABONATE 0.5% DRP?
Yes. 5 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, LOTEPREDNOL ETABONATE 0.5% DRP, is $10.5316 per ML — about 40% below LOTEPREDNOL ETABONATE 0.5% DRP.
Who manufactures LOTEPREDNOL ETABONATE 0.5% DRP?
LOTEPREDNOL ETABONATE 0.5% DRP (NDC 00574413515) is labeled by Padagis US LLC, and CMS classifies it as a generic product.