Product Information
DIPHENHYDRAMINE 12.5 MG/5 ML is a generic product labeled by Major Pharmaceuticals, priced at $0.0192 per ML under NDC 00904698520. Its NADAC has been published 342 times since Mar 18, 2020.
Strength
12.5 mg/5mL
Manufacturer
Major PharmaceuticalsNDC
00904698520
Classification
Generic
Dosage Form
SOLUTION
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
DIPHENHYDRAMINE HYDROCHLORIDEApproval Type
OTC MONOGRAPH DRUG
FDA Application
M012On Market Since
8/27/2019
Pharmacological Classes
Price Statistics
The NADAC for DIPHENHYDRAMINE 12.5 MG/5 ML has been published 342 times since Mar 18, 2020, and over the history we have for it it has risen 26.0%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0192 per ML |
|---|---|
| All-time high | $0.0199 (Jul 15, 2026) |
| All-time low | $0.0140 (Aug 18, 2021) |
| 52-week high | $0.0199 |
| 52-week low | $0.0173 |
| Median price | $0.0159 |
| Average price | $0.0161 |
| Largest weekly change | +21.5% (Jun 19, 2024) |
| Weeks tracked | 342 |
| Tracking since | Mar 18, 2020 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 9% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
Use these direct paths to move from a single NDC into the surrounding market, manufacturer, class, and trend context.
Manufacturer
Major Pharmaceuticals manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Diphenhydramine HCl market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Histamine-1 Receptor Antagonist class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of DIPHENHYDRAMINE 12.5 MG/5 ML?
The current National Average Drug Acquisition Cost (NADAC) for DIPHENHYDRAMINE 12.5 MG/5 ML, manufactured by Major Pharmaceuticals, is $0.0192 per ML (NDC 00904698520), effective Sep 30, 2026.
How has the price of DIPHENHYDRAMINE 12.5 MG/5 ML changed over time?
Over the history we have for it, the NADAC for DIPHENHYDRAMINE 12.5 MG/5 ML has risen 26.0%. It has been tracked across 342 weekly CMS publications since Mar 18, 2020.
What are the highest and lowest recorded NADAC prices for DIPHENHYDRAMINE 12.5 MG/5 ML?
Since Mar 18, 2020, the NADAC for DIPHENHYDRAMINE 12.5 MG/5 ML has ranged from a low of $0.0140 (Aug 18, 2021) to a high of $0.0199 (Jul 15, 2026), with a median of $0.0159 per ML.
Are there cheaper alternatives to DIPHENHYDRAMINE 12.5 MG/5 ML?
Yes. 3 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, CHILD ALLERGY RLF 12.5 MG/5 ML, is $0.0174 per ML — about 9% below DIPHENHYDRAMINE 12.5 MG/5 ML.
Who manufactures DIPHENHYDRAMINE 12.5 MG/5 ML?
DIPHENHYDRAMINE 12.5 MG/5 ML (NDC 00904698520) is labeled by Major Pharmaceuticals, and CMS classifies it as a generic product.