Product Information
DIPHENHYDRAMINE 12.5 MG/5 ML is a generic product labeled by Major Pharmaceuticals, priced at $0.0196 per ML under NDC 00904698520. Its NADAC has been published 336 times since Mar 18, 2020.
Strength
12.5 mg/5mL
Manufacturer
Major PharmaceuticalsNDC
00904698520
Classification
Generic
Dosage Form
SOLUTION
Route
ORAL
Effective Date
8/19/2026
Active Ingredients
DIPHENHYDRAMINE HYDROCHLORIDEApproval Type
OTC MONOGRAPH DRUG
FDA Application
M012On Market Since
8/27/2019
Pharmacological Classes
Price Statistics
The NADAC for DIPHENHYDRAMINE 12.5 MG/5 ML has been published 336 times since Mar 18, 2020, and over the history we have for it it has risen 28.6%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0196 per ML |
|---|---|
| All-time high | $0.0199 (Jul 15, 2026) |
| All-time low | $0.0140 (Aug 18, 2021) |
| 52-week high | $0.0199 |
| 52-week low | $0.0173 |
| Median price | $0.0159 |
| Average price | $0.0161 |
| Largest weekly change | +21.5% (Jun 19, 2024) |
| Weeks tracked | 336 |
| Tracking since | Mar 18, 2020 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 11% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of DIPHENHYDRAMINE 12.5 MG/5 ML?
The current National Average Drug Acquisition Cost (NADAC) for DIPHENHYDRAMINE 12.5 MG/5 ML, manufactured by Major Pharmaceuticals, is $0.0196 per ML (NDC 00904698520), effective Aug 19, 2026.
How has the price of DIPHENHYDRAMINE 12.5 MG/5 ML changed over time?
Over the history we have for it, the NADAC for DIPHENHYDRAMINE 12.5 MG/5 ML has risen 28.6%. It has been tracked across 336 weekly CMS publications since Mar 18, 2020.
What are the highest and lowest recorded NADAC prices for DIPHENHYDRAMINE 12.5 MG/5 ML?
Since Mar 18, 2020, the NADAC for DIPHENHYDRAMINE 12.5 MG/5 ML has ranged from a low of $0.0140 (Aug 18, 2021) to a high of $0.0199 (Jul 15, 2026), with a median of $0.0159 per ML.
Are there cheaper alternatives to DIPHENHYDRAMINE 12.5 MG/5 ML?
Yes. 3 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, CHILD ALLERGY RLF 12.5 MG/5 ML, is $0.0175 per ML — about 11% below DIPHENHYDRAMINE 12.5 MG/5 ML.
Who manufactures DIPHENHYDRAMINE 12.5 MG/5 ML?
DIPHENHYDRAMINE 12.5 MG/5 ML (NDC 00904698520) is labeled by Major Pharmaceuticals, and CMS classifies it as a generic product.