Product Information
BUPROPION HCL XL 300 MG TABLET is a generic product labeled by Rising Pharma Holdings Inc., priced at $0.1014 per EA under NDC 16571086350. Its NADAC has been published 203 times since Oct 5, 2022.
FDA first approved this application on Jan 28, 2019. Its Orange Book therapeutic-equivalence code is AB3 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
300 mg/1
Manufacturer
Rising Pharma Holdings Inc.NDC
16571086350
Classification
Generic
Dosage Form
TABLET, EXTENDED RELEASE
Route
ORAL
Effective Date
8/19/2026
Active Ingredients
BUPROPION HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA211020FDA Approved
1/28/2019
TE Code
AB3
On Market Since
8/1/2022
Pharmacological Classes
Price Statistics
The NADAC for BUPROPION HCL XL 300 MG TABLET has been published 203 times since Oct 5, 2022, and over the history we have for it it has declined 39.9%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.1014 per EA |
|---|---|
| All-time high | $0.1988 (Feb 14, 2024) |
| All-time low | $0.1014 (Aug 19, 2026) |
| 52-week high | $0.1492 |
| 52-week low | $0.1014 |
| Median price | $0.1515 |
| Average price | $0.1493 |
| Largest weekly change | -27.4% (Feb 21, 2024) |
| Weeks tracked | 203 |
| Tracking since | Oct 5, 2022 |
Generic Alternatives
The matcher finds 9 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of BUPROPION HCL XL 300 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for BUPROPION HCL XL 300 MG TABLET, manufactured by Rising Pharma Holdings Inc., is $0.1014 per EA (NDC 16571086350), effective Aug 19, 2026.
How has the price of BUPROPION HCL XL 300 MG TABLET changed over time?
Over the history we have for it, the NADAC for BUPROPION HCL XL 300 MG TABLET has declined 39.9%. It has been tracked across 203 weekly CMS publications since Oct 5, 2022.
What are the highest and lowest recorded NADAC prices for BUPROPION HCL XL 300 MG TABLET?
Since Oct 5, 2022, the NADAC for BUPROPION HCL XL 300 MG TABLET has ranged from a low of $0.1014 (Aug 19, 2026) to a high of $0.1988 (Feb 14, 2024), with a median of $0.1515 per EA.
Are there cheaper alternatives to BUPROPION HCL XL 300 MG TABLET?
9 manufacturers publish a NADAC-priced product with the same active ingredient and strength as BUPROPION HCL XL 300 MG TABLET in a comparable dosage form, but none are currently priced below it.
Who manufactures BUPROPION HCL XL 300 MG TABLET?
BUPROPION HCL XL 300 MG TABLET (NDC 16571086350) is labeled by Rising Pharma Holdings Inc., and CMS classifies it as a generic product.