Product Information
AMITRIPTYLINE HCL 25 MG TAB is a generic product labeled by Sun Pharmaceutical Industries Inc., priced at $0.0522 per EA under NDC 57664068888. Its NADAC has been published 427 times since Aug 1, 2018.
FDA first approved this application on Jul 14, 1987. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
25 mg/1
Manufacturer
Sun Pharmaceutical Industries Inc.NDC
57664068888
Classification
Generic
Dosage Form
TABLET, FILM COATED
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
AMITRIPTYLINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA089399FDA Approved
7/14/1987
TE Code
AB
On Market Since
7/14/1987
Pharmacological Classes
Price Statistics
The NADAC for AMITRIPTYLINE HCL 25 MG TAB has been published 427 times since Aug 1, 2018, and over the history we have for it it has declined 72.8%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0522 per EA |
|---|---|
| All-time high | $0.1918 (Aug 15, 2018) |
| All-time low | $0.0411 (Nov 20, 2024) |
| 52-week high | $0.0566 |
| 52-week low | $0.0509 |
| Median price | $0.0678 |
| Average price | $0.0840 |
| Largest weekly change | -27.3% (Nov 20, 2024) |
| Weeks tracked | 427 |
| Tracking since | Aug 1, 2018 |
Generic Alternatives
The matcher finds 12 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Sun Pharmaceutical Industries Inc. manufacturer profile
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Drug market
Amitriptyline Hydrochloride market comparison
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Therapeutic class
Tricyclic Antidepressant class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of AMITRIPTYLINE HCL 25 MG TAB?
The current National Average Drug Acquisition Cost (NADAC) for AMITRIPTYLINE HCL 25 MG TAB, manufactured by Sun Pharmaceutical Industries Inc., is $0.0522 per EA (NDC 57664068888), effective Sep 30, 2026.
How has the price of AMITRIPTYLINE HCL 25 MG TAB changed over time?
Over the history we have for it, the NADAC for AMITRIPTYLINE HCL 25 MG TAB has declined 72.8%. It has been tracked across 427 weekly CMS publications since Aug 1, 2018.
What are the highest and lowest recorded NADAC prices for AMITRIPTYLINE HCL 25 MG TAB?
Since Aug 1, 2018, the NADAC for AMITRIPTYLINE HCL 25 MG TAB has ranged from a low of $0.0411 (Nov 20, 2024) to a high of $0.1918 (Aug 15, 2018), with a median of $0.0678 per EA.
Are there cheaper alternatives to AMITRIPTYLINE HCL 25 MG TAB?
12 manufacturers publish a NADAC-priced product with the same active ingredient and strength as AMITRIPTYLINE HCL 25 MG TAB in a comparable dosage form, but none are currently priced below it.
Who manufactures AMITRIPTYLINE HCL 25 MG TAB?
AMITRIPTYLINE HCL 25 MG TAB (NDC 57664068888) is labeled by Sun Pharmaceutical Industries Inc., and CMS classifies it as a generic product.