Product Information
ESTRADIOL 0.1% (1.25 MG) GEL PK is a generic product labeled by Encube Ethicals, Inc., priced at $0.8042 per GM under NDC 21922009052. Its NADAC has been published 37 times since Dec 10, 2025.
FDA first approved this application on Mar 5, 2025. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
1.25 mg/1.25g
Manufacturer
Encube Ethicals, Inc.NDC
21922009052
Classification
Generic
Dosage Form
GEL
Route
TOPICAL
Effective Date
8/19/2026
Active Ingredients
ESTRADIOLApproval Type
Generic (ANDA)
FDA Application
ANDA218507FDA Approved
3/5/2025
TE Code
AB
On Market Since
3/10/2025
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.1% (1.25 MG) GEL PK has been published 37 times since Dec 10, 2025, and over the history we have for it it has declined 43.1%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.8042 per GM |
|---|---|
| All-time high | $1.4125 (Dec 10, 2025) |
| All-time low | $0.8042 (Aug 19, 2026) |
| 52-week high | $1.4125 |
| 52-week low | $0.8042 |
| Median price | $1.1830 |
| Average price | $1.1967 |
| Largest weekly change | -21.1% (Aug 19, 2026) |
| Weeks tracked | 37 |
| Tracking since | Dec 10, 2025 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.1% (1.25 MG) GEL PK?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.1% (1.25 MG) GEL PK, manufactured by Encube Ethicals, Inc., is $0.8042 per GM (NDC 21922009052), effective Aug 19, 2026.
How has the price of ESTRADIOL 0.1% (1.25 MG) GEL PK changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.1% (1.25 MG) GEL PK has declined 43.1%. It has been tracked across 37 weekly CMS publications since Dec 10, 2025.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.1% (1.25 MG) GEL PK?
Since Dec 10, 2025, the NADAC for ESTRADIOL 0.1% (1.25 MG) GEL PK has ranged from a low of $0.8042 (Aug 19, 2026) to a high of $1.4125 (Dec 10, 2025), with a median of $1.1830 per GM.
Are there cheaper alternatives to ESTRADIOL 0.1% (1.25 MG) GEL PK?
3 manufacturers publish a NADAC-priced product with the same active ingredient and strength as ESTRADIOL 0.1% (1.25 MG) GEL PK in a comparable dosage form, but none are currently priced below it.
Who manufactures ESTRADIOL 0.1% (1.25 MG) GEL PK?
ESTRADIOL 0.1% (1.25 MG) GEL PK (NDC 21922009052) is labeled by Encube Ethicals, Inc., and CMS classifies it as a generic product.