Product Information
ACYCLOVIR 5% OINTMENT is a generic product labeled by Macleods Pharmaceuticals Limited, priced at $0.5808 per GM under NDC 33342043915. Its NADAC has been published 151 times since Feb 23, 2022.
FDA first approved this application on May 19, 2021. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
50 mg/g
Manufacturer
Macleods Pharmaceuticals LimitedNDC
33342043915
Classification
Generic
Dosage Form
OINTMENT
Route
TOPICAL
Effective Date
4/23/2025
Active Ingredients
ACYCLOVIRApproval Type
Generic (ANDA)
FDA Application
ANDA212444FDA Approved
5/19/2021
TE Code
AB
On Market Since
8/13/2018
Pharmacological Classes
Price Statistics
The NADAC for ACYCLOVIR 5% OINTMENT has been published 151 times since Feb 23, 2022, and over the history we have for it it has declined 39.8%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.5808 per GM |
|---|---|
| All-time high | $1.3693 (Apr 13, 2022) |
| All-time low | $0.4269 (Nov 20, 2024) |
| Median price | $0.7527 |
| Average price | $0.7508 |
| Largest weekly change | +46.7% (Aug 17, 2022) |
| Weeks tracked | 151 |
| Tracking since | Feb 23, 2022 |
1W
N/A
1M
N/A
3M
N/A
6M
N/A
1Y
N/A
3Y
-18.4%
5Y
N/A
All
-39.8%
Last surveyed May 14, 2025 — this NDC no longer appears in the current weekly NADAC file.
Generic Alternatives
The matcher finds 5 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 40% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Macleods Pharmaceuticals Limited manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Acyclovir market comparison
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Therapeutic class
Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of ACYCLOVIR 5% OINTMENT?
The current National Average Drug Acquisition Cost (NADAC) for ACYCLOVIR 5% OINTMENT, manufactured by Macleods Pharmaceuticals Limited, is $0.5808 per GM (NDC 33342043915), effective May 14, 2025.
How has the price of ACYCLOVIR 5% OINTMENT changed over time?
Over the history we have for it, the NADAC for ACYCLOVIR 5% OINTMENT has declined 39.8%. It has been tracked across 151 weekly CMS publications since Feb 23, 2022.
What are the highest and lowest recorded NADAC prices for ACYCLOVIR 5% OINTMENT?
Since Feb 23, 2022, the NADAC for ACYCLOVIR 5% OINTMENT has ranged from a low of $0.4269 (Nov 20, 2024) to a high of $1.3693 (Apr 13, 2022), with a median of $0.7527 per GM.
Are there cheaper alternatives to ACYCLOVIR 5% OINTMENT?
Yes. 5 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, ACYCLOVIR 5% OINTMENT, is $0.3458 per GM — about 40% below ACYCLOVIR 5% OINTMENT.
Who manufactures ACYCLOVIR 5% OINTMENT?
ACYCLOVIR 5% OINTMENT (NDC 33342043915) is labeled by Macleods Pharmaceuticals Limited, and CMS classifies it as a generic product.