Product Information
NAPROXEN 375 MG TABLET is a generic product labeled by ScieGen Pharmaceuticals, Inc., priced at $0.0588 per EA under NDC 50228043505. Its NADAC has been published 325 times since Jul 15, 2020.
FDA first approved this application on Feb 21, 2020. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
375 mg/1
Manufacturer
ScieGen Pharmaceuticals, Inc.NDC
50228043505
Classification
Generic
Dosage Form
TABLET
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
NAPROXENApproval Type
Generic (ANDA)
FDA Application
ANDA212517FDA Approved
2/21/2020
TE Code
AB
On Market Since
3/1/2020
Pharmacological Classes
Price Statistics
The NADAC for NAPROXEN 375 MG TABLET has been published 325 times since Jul 15, 2020, and over the history we have for it it has declined 21.2%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0588 per EA |
|---|---|
| All-time high | $0.0808 (Jun 16, 2021) |
| All-time low | $0.0474 (Apr 17, 2024) |
| 52-week high | $0.0601 |
| 52-week low | $0.0561 |
| Median price | $0.0673 |
| Average price | $0.0666 |
| Largest weekly change | -28.8% (Apr 17, 2024) |
| Weeks tracked | 325 |
| Tracking since | Jul 15, 2020 |
Generic Alternatives
The matcher finds 10 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 3% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
ScieGen Pharmaceuticals, Inc. manufacturer profile
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Drug market
Naproxen market comparison
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Therapeutic class
Nonsteroidal Anti-inflammatory Drug class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of NAPROXEN 375 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for NAPROXEN 375 MG TABLET, manufactured by ScieGen Pharmaceuticals, Inc., is $0.0588 per EA (NDC 50228043505), effective Sep 30, 2026.
How has the price of NAPROXEN 375 MG TABLET changed over time?
Over the history we have for it, the NADAC for NAPROXEN 375 MG TABLET has declined 21.2%. It has been tracked across 325 weekly CMS publications since Jul 15, 2020.
What are the highest and lowest recorded NADAC prices for NAPROXEN 375 MG TABLET?
Since Jul 15, 2020, the NADAC for NAPROXEN 375 MG TABLET has ranged from a low of $0.0474 (Apr 17, 2024) to a high of $0.0808 (Jun 16, 2021), with a median of $0.0673 per EA.
Are there cheaper alternatives to NAPROXEN 375 MG TABLET?
Yes. 10 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, NAPROXEN 375 MG TABLET, is $0.0573 per EA — about 3% below NAPROXEN 375 MG TABLET.
Who manufactures NAPROXEN 375 MG TABLET?
NAPROXEN 375 MG TABLET (NDC 50228043505) is labeled by ScieGen Pharmaceuticals, Inc., and CMS classifies it as a generic product.