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Product Information

BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG CAPSULE is a generic product labeled by Mayne Pharma, priced at $2.0089 per EA under NDC 51862017901. Its NADAC has been published 637 times since Nov 28, 2013.

FDA first approved this application on Mar 17, 1986. Its Orange Book therapeutic-equivalence code is AA.

BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG CAPSULE

butalbital, acetaminophen and caffeine
$2.0089per EA
Discontinued

Strength

325; 50; 40 mg/1; mg/1; mg/1

Manufacturer

Mayne Pharma

NDC

51862017901

Classification

Generic

Dosage Form

CAPSULE

Route

ORAL

Effective Date

8/19/2026

Approval Type

Generic (ANDA)

FDA Application

ANDA089007

FDA Approved

3/17/1986

TE Code

AA

On Market Since

4/16/2012

Pharmacological Classes

Barbiturate
Barbiturates
Central Nervous System Stimulant
Central Nervous System Stimulation
Methylxanthine
Xanthines

Price Statistics

The NADAC for BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG CAPSULE has been published 637 times since Nov 28, 2013, and over the history we have for it it has risen 259.1%. The table below summarizes its recorded NADAC range and movement.

Current price$2.0089 per EA
All-time high$3.8847 (May 15, 2019)
All-time low$0.2999 (Mar 18, 2015)
52-week high$2.3000
52-week low$1.6931
Median price$2.2809
Average price$2.2971
Largest weekly change+397.0% (May 20, 2015)
Weeks tracked637
Tracking sinceNov 28, 2013

Price History

1W

N/A

1M

0.0%

3M

+18.6%

6M

+7.8%

1Y

-12.7%

3Y

-18.1%

5Y

-32.0%

All

+259.1%

Last surveyed Sep 16, 2026 — this NDC no longer appears in the current weekly NADAC file.

Generic Alternatives

The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 16% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.

Lowest-Cost Alternatives

Save up to 16%

3 alternatives • Same active ingredient

BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG CAPSULE
Generic
13925053601•Seton Pharmaceuticals
$1.6931
Save 16%
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG CAPSULE
Generic
75907000901•Dr. Reddy's Laboratories Inc.
$1.9312
Save 4%
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG CAPSULE
Generic
00527409437•Lannett Company Inc.
$1.9312
Save 4%

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$0.0621
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TENSION HEADACHE CAPLET
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70000015901•Cardinal Health
$0.0622
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TENSION HEADACHE CAPLET
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70000015902•Cardinal Health
$0.0622
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QC HEADACHE RELIEF TABLET
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63868048501•Chain Drug Marketing Association
$0.0629
per EA
GS MIGRAINE 250-250-65 MG CPLT
Generic
00113037462•L. Perrigo Company
$0.0648
per EA
GS MIGRAINE 250-250-65 MG CPLT
Generic
00113037478•L. Perrigo Company
$0.0648
per EA
PAIN RELIEVER PLS 250-250-65 MG
Generic
00536132601•Rugby Laboratories
$0.0648
per EA
MIGRAINE 250-250-65 MG CPLT
Generic
24385036571•AmerisourceBergen
$0.0648
per EA
MIGRAINE FORMULA CAPLET
Generic
24385036578•AmerisourceBergen
$0.0648
per EA

Continue researching this drug

Use these direct paths to move from a single NDC into the surrounding market, manufacturer, class, and trend context.

Manufacturer

Mayne Pharma manufacturer profile

See the full portfolio, pricing trend, and other products from this labeler.

Drug market

butalbital, acetaminophen and caffeine market comparison

Compare this molecule across participating manufacturers and inspect the broader market price spread.

Therapeutic class

Barbiturate class view

See how this drug behaves alongside other products in the same FDA pharmacologic class.

Trend hub

Latest market trends

Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.

Guide

Understanding NADAC pricing

Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.

Frequently asked questions

What is the NADAC price of BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG CAPSULE?

The current National Average Drug Acquisition Cost (NADAC) for BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG CAPSULE, manufactured by Mayne Pharma, is $2.0089 per EA (NDC 51862017901), effective Sep 16, 2026.

How has the price of BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG CAPSULE changed over time?

Over the history we have for it, the NADAC for BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG CAPSULE has risen 259.1%. It has been tracked across 637 weekly CMS publications since Nov 28, 2013.

What are the highest and lowest recorded NADAC prices for BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG CAPSULE?

Since Nov 28, 2013, the NADAC for BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG CAPSULE has ranged from a low of $0.2999 (Mar 18, 2015) to a high of $3.8847 (May 15, 2019), with a median of $2.2809 per EA.

Are there cheaper alternatives to BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG CAPSULE?

Yes. 3 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG CAPSULE, is $1.6931 per EA — about 16% below BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG CAPSULE.

Who manufactures BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG CAPSULE?

BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG CAPSULE (NDC 51862017901) is labeled by Mayne Pharma, and CMS classifies it as a generic product.