Methylxanthine

122 drugs across 47 manufacturers|103 Generic,19 Brand

The Methylxanthine class contains 122 NDCs from 47 manufacturers (103 generic, 19 brand), at an average NADAC of $1.12 per unit. Every drug, manufacturer, and price in this FDA-defined pharmacologic class is listed below.

Total Drugs

122

103G / 19B

Manufacturers

Avg $1.1200/unit

Avg 7d Change

-1.15%

Across 84 drugs with changes

7d Activity

17↑67↓38 flat

of 122 total drugs

Class Price Trend

Monthly average NADAC price per unit, split by generic and brand

Manufacturer Breakdown

47 manufacturers producing drugs in this therapeutic class(5 pricing outliers)

Haleon US Holdings LLC

Westminster Pharmaceuticals LLC

Quagen Pharmaceuticals LLC

4 drugs

$0.6230

avg/unit

Glenmark Pharmaceuticals Inc., USA

Chain Drug Marketing Association

4 drugs

$0.0701

avg/unit

and 35 more manufacturers

Drug Portfolio

122 drugs total, 122 shown

Drug ↕	NDC	Price	7d Change ↕	Class	Market Outlier	Manufacturer ↕
MIGERGOT SUPPOSITORY Ergotamine Tartrate and Caffeine	00713016612	$23.7433 per EA	—	Generic	—	Cosette Pharmaceuticals, Inc.
THEO-24 ER 400 MG CAPSULE theophylline anhydrous	52244040010	$9.7932 per EA	—	—	—	Endo USA Inc.
FIORICET 50-300-40 MG CAPSULE Butalbital, Acetaminophen, and Caffeine	52544008001	$8.8237 per EA	—	—	High Outlier	Actavis Pharma, Inc.
CAFFEINE CIT 60 MG/3 ML ORAL caffeine citrate	25021060203	$8.2577 per ML	—	Generic	—	Sagent Pharmaceuticals
CAFFEINE CIT 60 MG/3 ML ORAL Caffeine Citrate	47335029044	$8.2577 per ML	—	Generic	—	Sun Pharmaceutical Industries Inc.
THEO-24 ER 300 MG CAPSULE theophylline anhydrous	52244030010	$6.9529 per EA	—	—	—	Endo USA Inc.
THEO-24 ER 200 MG CAPSULE theophylline anhydrous	52244020010	$5.6678 per EA	—	—	—	Endo USA Inc.
BUTALBITAL-ACETAMINOPHEN-CAFFEINE-CODEINE 50-300-40-30 MG CP Butalbital, Acetaminophen, Caffeine and Codeine Phosphate	00054065025	$5.2969 per EA	-0.31%	Generic	—	Hikma Pharmaceuticals USA Inc.
BUTALBITAL-ACETAMINOPHEN-CAFFEINE-CODEINE 50-300-40-30 MG CP Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate	00591264101	$5.2969 per EA	-0.31%	Generic	—	Actavis Pharma, Inc.
THEO-24 ER 100 MG CAPSULE theophylline anhydrous	52244010010	$3.8161 per EA	—	—	—	Endo USA Inc.
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG CAPSULE butalbital, acetaminophen and caffeine	51862017901	$2.0089 per EA	—	Generic	—	Mayne Pharma
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG CAPSULE butalbital, acetaminophen and caffeine	00527409437	$1.9312 per EA	-3.87%	Generic	—	Lannett Company Inc.
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG CAPSULE Butalbital, Acetaminophen and Caffeine	13107007501	$1.9312 per EA	-3.87%	Generic	—	Aurolife Pharma LLC
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG CAPSULE BUTALBITAL, ACETAMINOPHEN AND CAFFEINE	70752014110	$1.9312 per EA	-3.87%	Generic	—	Quagen Pharmaceuticals LLC
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG CAPSULE butalbital, acetaminophen and caffeine	75907000901	$1.9312 per EA	-3.87%	Generic	—	Dr. Reddy's Laboratories Inc.
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG CAPSULE butalbital, acetaminophen and caffeine	13925053601	$1.6931 per EA	—	Generic	—	Seton Pharmaceuticals
THEOPHYLLINE ER 600 MG TABLET Theophylline	68462035601	$1.3952 per EA	—	Generic	High Outlier	Glenmark Pharmaceuticals Inc., USA
THEOPHYLLINE ER 600 MG TABLET Theophylline Anhydrous	69367041501	$1.3952 per EA	—	Generic	—	Westminster Pharmaceuticals LLC
THEOPHYLLINE ER 450 MG TABLET Theophylline	70095001801	$1.1149 per EA	—	Generic	High Outlier	Sun Pharmaceutical Industries Inc.
THEOPHYLLINE ER 450 MG TABLET Theophylline	00480330901	$1.0992 per EA	+4.65%	Generic	—	Teva Pharmaceuticals USA Inc.
THEOPHYLLINE ER 450 MG TABLET Theophylline	23155074201	$1.0992 per EA	+4.65%	Generic	—	Heritage Pharmaceuticals Inc.
THEOPHYLLINE ER 450 MG TABLET Theophylline	31722007801	$1.0992 per EA	+4.65%	Generic	—	Camber Pharmaceuticals Inc.
THEOPHYLLINE ER 450 MG TABLET theophylline	60219204601	$1.0992 per EA	+4.65%	Generic	—	Amneal Pharmaceuticals NY LLC
THEOPHYLLINE ER 450 MG TABLET Theophylline	62332002631	$1.0992 per EA	+4.65%	Generic	—	Alembic Pharmaceuticals Inc.
THEOPHYLLINE ER 450 MG TABLET Theophylline	64380024401	$1.0992 per EA	+4.65%	Generic	—	Strides Pharma Inc.
THEOPHYLLINE ER 450 MG TABLET Theophylline	68462072201	$1.0992 per EA	+4.65%	Generic	High Outlier	Glenmark Pharmaceuticals Inc., USA
THEOPHYLLINE ER 450 MG TABLET THEOPHYLLINE	69315022701	$1.0992 per EA	+4.65%	Generic	—	Leading Pharma, LLC
THEOPHYLLINE ER 450 MG TABLET Theophylline	72578017401	$1.0992 per EA	+4.65%	Generic	—	Viona Pharmaceuticals Inc.
ASCOMP WITH CODEINE CAPSULE Butalbital, Aspirin, Caffeine and Codeine Phosphate	51991007401	$1.0039 per EA	-1.80%	Generic	—	Breckenridge Pharmaceutical Inc.
ASCOMP WITH CODEINE CAPSULE Butalbital, Aspirin, Caffeine and Codeine Phosphate	51991007405	$1.0039 per EA	-1.80%	Generic	—	Breckenridge Pharmaceutical Inc.
ASA-BUTALB-CAFF-COD #3 CAPSULE BUTALBITAL, ASPIRIN, CAFFEINE and CODEINE PHOSPHATE	69238199301	$1.0039 per EA	-1.80%	Generic	—	Amneal Pharmaceuticals of New York LLC
THEOPHYLLINE ER 400 MG TABLET Theophylline	42858070101	$0.9953 per EA	-1.96%	Generic	High Outlier	Rhodes Pharmaceuticals L.P.
THEOPHYLLINE ER 400 MG TABLET Theophylline	68462038001	$0.9953 per EA	-1.96%	Generic	High Outlier	Glenmark Pharmaceuticals Inc., USA
THEOPHYLLINE ER 400 MG TABLET Theophylline Anhydrous	69367041401	$0.9953 per EA	-1.96%	Generic	—	Westminster Pharmaceuticals LLC
BUTALBITAL-ASPIRIN-CAFFEINE 50-325-40 MG CAPSULE Butalbital, aspirin, and caffeine	00527155201	$0.9482 per EA	-2.12%	Generic	—	Lannett Company Inc.
BUTALBITAL-ASPIRIN-CAFFEINE 50-325-40 MG CAPSULE Butalbital, aspirin, and caffeine	00781227001	$0.9482 per EA	-2.12%	Generic	—	Sandoz Inc.
BUTALBITAL-ASPIRIN-CAFFEINE 50-325-40 MG CAPSULE butalbital, aspirin, and caffeine	62135043390	$0.9482 per EA	-2.12%	Generic	—	Chartwell RX LLC
BUTALBITAL-ASPIRIN-CAFFEINE 50-325-40 MG CAPSULE BUTALBITAL, ASPIRIN, AND CAFFEINE	69367041601	$0.9482 per EA	-2.12%	Generic	—	Westminster Pharmaceuticals LLC
BUTALBITAL-ACETAMINOPHEN-CAFFEINE-CODEINE 50-325-40-30 MG CP Butalbital, Acetaminophen, Caffeine and Codeine Phosphate	00054300001	$0.7978 per EA	-0.46%	Generic	—	Hikma Pharmaceuticals USA Inc.
BUTALBITAL-ACETAMINOPHEN-CAFFEINE-CODEINE 50-325-40-30 MG CP Butalbital, Acetaminophen, Caffeine, and Codeine Phosphate	00591322001	$0.7978 per EA	-0.46%	Generic	—	Actavis Pharma, Inc.
BUTALBITAL-ACETAMINOPHEN-CAFFEINE-CODEINE 50-325-40-30 MG CP Butalbital, Acetaminophen, Caffeine and Codeine Phosphate	51991007301	$0.7978 per EA	-0.46%	Generic	—	Breckenridge Pharmaceutical Inc.
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-300-40 MG CAPSULE butalbital, acetaminophen and caffeine	11534018704	$0.3980 per EA	—	Generic	—	Sunrise Pharmaceutical Inc.
THEOPHYLLINE ER 300 MG TABLET Theophylline	70095001701	$0.3422 per EA	—	Generic	High Outlier	Sun Pharmaceutical Industries Inc.
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-300-40 MG CAPSULE Butalbital, Acetaminophen, and Caffeine	16714017001	$0.3355 per EA	—	Generic	—	NorthStar Rx LLC
THEOPHYLLINE ER 300 MG TABLET Theophylline	00480331001	$0.3295 per EA	-3.69%	Generic	—	Teva Pharmaceuticals USA Inc.
THEOPHYLLINE ER 300 MG TABLET Theophylline	23155074101	$0.3295 per EA	-3.69%	Generic	—	Heritage Pharmaceuticals Inc.
THEOPHYLLINE ER 300 MG TABLET Theophylline	31722007701	$0.3295 per EA	-3.69%	Generic	—	Camber Pharmaceuticals Inc.
THEOPHYLLINE ER 300 MG TABLET theophylline	60219204501	$0.3295 per EA	-3.69%	Generic	—	Amneal Pharmaceuticals NY LLC
THEOPHYLLINE ER 300 MG TABLET Theophylline	62135045790	$0.3295 per EA	-3.69%	Generic	Low Outlier	Chartwell RX LLC
THEOPHYLLINE ER 300 MG TABLET Theophylline	62332002531	$0.3295 per EA	-3.69%	Generic	—	Alembic Pharmaceuticals Inc.
THEOPHYLLINE ER 300 MG TABLET Theophylline	64380024301	$0.3295 per EA	-3.69%	Generic	—	Strides Pharma Inc.
THEOPHYLLINE ER 300 MG TABLET Theophylline	68462072101	$0.3295 per EA	-3.69%	Generic	High Outlier	Glenmark Pharmaceuticals Inc., USA
THEOPHYLLINE ER 300 MG TABLET THEOPHYLLINE	69315022601	$0.3295 per EA	-3.69%	Generic	—	Leading Pharma, LLC
THEOPHYLLINE ER 300 MG TABLET Theophylline	69452026720	$0.3295 per EA	-3.69%	Generic	Low Outlier	Bionpharma Inc.
THEOPHYLLINE ER 300 MG TABLET Theophylline	72578017301	$0.3295 per EA	-3.69%	Generic	—	Viona Pharmaceuticals Inc.
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-300-40 MG CAPSULE Butalbital, Acetaminophen, and Caffeine Capsules	00527409537	$0.3163 per EA	+0.06%	Generic	—	Lannett Company Inc.
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-300-40 MG CAPSULE Butalbital, Acetaminophen, and Caffeine	00591264001	$0.3163 per EA	+0.06%	Generic	High Outlier	Actavis Pharma, Inc.
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-300-40 MG CAPSULE Butalbital, Acetaminophen, and Caffeine	00591264005	$0.3163 per EA	+0.06%	Generic	High Outlier	Actavis Pharma, Inc.
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-300-40 MG CAPSULE butalbital, acetaminophen and caffeine	11534018701	$0.3163 per EA	+0.06%	Generic	—	Sunrise Pharmaceutical Inc.
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-300-40 MG CAPSULE butalbital, acetaminophen and caffeine	43547068610	$0.3163 per EA	+0.06%	Generic	—	Solco Healthcare US LLC
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-300-40 MG CAPSULE butalbital, acetaminophen, and caffeine	51672422201	$0.3163 per EA	+0.06%	Generic	—	Taro Pharmaceuticals U.S.A. Inc.
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-300-40 MG CAPSULE Butalbital, Acetaminophen and Caffeine	70010004401	$0.3163 per EA	+0.06%	Generic	—	Granules Pharmaceuticals Inc.
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-300-40 MG CAPSULE BUTALBITAL, ACETAMINOPHEN AND CAFFEINE	70752014410	$0.3163 per EA	+0.06%	Generic	—	Quagen Pharmaceuticals LLC
EXCEDRIN MIGRAINE CAPLET Acetaminophen, Aspirin (NSAID) and Caffeine	00067203991	$0.1450 per EA	—	Brand OTC	—	Haleon US Holdings LLC
EXCEDRIN MIGRAINE CAPLET Acetaminophen, Aspirin (NSAID) and Caffeine	00067203992	$0.1450 per EA	—	Brand OTC	—	Haleon US Holdings LLC
EXCEDRIN EXTRA STRENGTH CAPLET Acetaminophen, Aspirin (NSAID), and Caffeine	00067200020	$0.1338 per EA	—	Brand OTC	—	Haleon US Holdings LLC
EXCEDRIN EXTRA STRENGTH CAPLET Acetaminophen, Aspirin (NSAID), and Caffeine	00067200024	$0.1338 per EA	—	Brand OTC	—	Haleon US Holdings LLC
EXCEDRIN EXTRA STRENGTH CAPLET Acetaminophen, Aspirin (NSAID), and Caffeine	00067200033	$0.1338 per EA	—	Brand OTC	—	Haleon US Holdings LLC
EXCEDRIN EXTRA STRENGTH CAPLET Acetaminophen, Aspirin (NSAID), and Caffeine	00067200050	$0.1338 per EA	—	Brand OTC	—	Haleon US Holdings LLC
EXCEDRIN EXTRA STRENGTH CAPLET Acetaminophen, Aspirin (NSAID), and Caffeine	00067200077	$0.1338 per EA	—	Brand OTC	—	Haleon US Holdings LLC
EXCEDRIN EXTRA STRENGTH CAPLET Acetaminophen, Aspirin (NSAID), and Caffeine	00067200091	$0.1338 per EA	—	Brand OTC	—	Haleon US Holdings LLC
EXCEDRIN MIGRAINE GELTAB Acetaminophen, Asprin, Caffeine	00067203520	$0.1338 per EA	—	Brand OTC	—	Haleon US Holdings LLC
EXCEDRIN MIGRAINE CAPLET Acetaminophen, Aspirin (NSAID) and Caffeine	00067203924	$0.1338 per EA	—	Brand OTC	—	Haleon US Holdings LLC
EXCEDRIN MIGRAINE CAPLET Acetaminophen, Aspirin (NSAID) and Caffeine	00067203933	$0.1338 per EA	—	Brand OTC	—	Haleon US Holdings LLC
EXCEDRIN MIGRAINE CAPLET Acetaminophen, Aspirin (NSAID) and Caffeine	00067203950	$0.1338 per EA	—	Brand OTC	—	Haleon US Holdings LLC
EXCEDRIN MIGRAINE CAPLET Acetaminophen, Aspirin (NSAID) and Caffeine	00067203977	$0.1338 per EA	—	Brand OTC	—	Haleon US Holdings LLC
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG TABLET Butalbital, Acetaminophen, and Caffeine	60687067265	$0.1234 per EA	—	Generic	—	American Health Packaging
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG TABLET Butalbital, Acetaminophen, and Caffeine	00527169501	$0.1223 per EA	-0.82%	Generic	—	Lannett Company Inc.
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG TABLET Butalbital, Acetaminophen, and Caffeine	00527169505	$0.1223 per EA	-0.82%	Generic	—	Lannett Company Inc.
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG TABLET Butalbital, Acetaminophen, and Caffeine	00591336901	$0.1223 per EA	-0.82%	Generic	High Outlier	Actavis Pharma, Inc.
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG TABLET Butalbital, Acetaminophen, and Caffeine	00591336905	$0.1223 per EA	-0.82%	Generic	High Outlier	Actavis Pharma, Inc.
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG TABLET Butalbital, Acetaminophen, and Caffeine	00904693806	$0.1223 per EA	-0.82%	Generic	—	Major Pharmaceuticals
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG TABLET Butalbital, Acetaminophen and Caffeine	10702025301	$0.1223 per EA	-0.82%	Generic	—	KVK-Tech Inc.
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG TABLET Butalbital, Acetaminophen and Caffeine	10702025350	$0.1223 per EA	-0.82%	Generic	—	KVK-Tech Inc.
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG TABLET butalbital, acetaminophen and caffeine	46672005310	$0.1223 per EA	-0.82%	Generic	—	Mikart, LLC
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG TABLET butalbital, acetaminophen and caffeine	46672005350	$0.1223 per EA	-0.82%	Generic	—	Mikart, LLC
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG TABLET Butalbital, Acetaminophen, and Caffeine	50268055313	$0.1223 per EA	-0.82%	Generic	—	AvPAK
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG TABLET BUTALBITAL, ACETAMINOPHEN AND CAFFEINE	62135075101	$0.1223 per EA	-0.82%	Generic	—	Chartwell RX LLC
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG TABLET Butalbital, Acetaminophen, and Caffeine	64380015701	$0.1223 per EA	-0.82%	Generic	—	Strides Pharma Inc.
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG TABLET Butalbital, Acetaminophen, and Caffeine	64380015702	$0.1223 per EA	-0.82%	Generic	—	Strides Pharma Inc.
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG TABLET Butalbital, Acetaminophen, and Caffeine	69367020301	$0.1223 per EA	-0.82%	Generic	—	Westminster Pharmaceuticals LLC
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG TABLET Butalbital, Acetaminophen, and Caffeine	69367020305	$0.1223 per EA	-0.82%	Generic	—	Westminster Pharmaceuticals LLC
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG TABLET Butalbital, Acetaminophen and Caffeine	70010014901	$0.1223 per EA	-0.82%	Generic	—	Granules Pharmaceuticals Inc.
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG TABLET Butalbital, Acetaminophen and Caffeine	70010014905	$0.1223 per EA	-0.82%	Generic	—	Granules Pharmaceuticals Inc.
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG TABLET BUTALBITAL, ACETAMINOPHEN AND CAFFEINE	70752014210	$0.1223 per EA	-0.82%	Generic	—	Quagen Pharmaceuticals LLC
BUTALBITAL-ACETAMINOPHEN-CAFFEINE 50-325-40 MG TABLET BUTALBITAL, ACETAMINOPHEN AND CAFFEINE	70752014214	$0.1223 per EA	-0.82%	Generic	—	Quagen Pharmaceuticals LLC
EXCEDRIN EXTRA STRENGTH GELTAB Acetaminophen, Asprin, Caffeine	00067202124	$0.1205 per EA	—	Brand OTC	—	Haleon US Holdings LLC
THEOPHYLLINE 80 MG/15 ML SOLN Theophylline	27808003301	$0.1118 per ML	—	Generic	Low Outlier	Cranbury Pharmaceuticals, LLC
THEOPHYLLINE 80 MG/15 ML SOLN Theophylline	62135055647	$0.1118 per ML	—	Generic	Low Outlier	Chartwell RX LLC
ALERT AID 200 MG TABLET Caffeine	46122045773	$0.0830 per EA	-2.13%	Generic OTC	—	AmerisourceBergen
CAFFEINE 200 MG TABLET Caffeine	70000040901	$0.0830 per EA	-2.13%	Generic OTC	—	Cardinal Health
FT STAY AWAKE 200 MG TABLET caffeine	70677112601	$0.0830 per EA	-2.13%	Generic OTC	—	Strategic Sourcing Services LLC
QC STAY AWAKE 200 MG TABLET Caffeine	83324007416	$0.0830 per EA	-2.13%	Generic OTC	—	Chain Drug Marketing Association
QC HEADACHE 250-250-65 MG TAB Acetaminophen, Aspirin, Caffeine	83324006324	$0.0672 per EA	—	Generic OTC	High Outlier	Chain Drug Marketing Association
QC MIGRAINE 250-250-65 MG CPLT ACETAMINOPHEN, ASPIRIN and CAFFEINE	83324009924	$0.0672 per EA	—	Generic OTC	—	Chain Drug Marketing Association
GS MIGRAINE 250-250-65 MG CPLT Acetaminophen, Aspirin, Caffeine	00113037462	$0.0648 per EA	-0.15%	Generic OTC	—	L. Perrigo Company
GS MIGRAINE 250-250-65 MG CPLT Acetaminophen, Aspirin, Caffeine	00113037478	$0.0648 per EA	-0.15%	Generic OTC	—	L. Perrigo Company
PAIN RELIEVER PLS 250-250-65 MG Acetaminophen, Aspirin, Caffeine	00536132601	$0.0648 per EA	-0.15%	Generic OTC	—	Rugby Laboratories
MIGRAINE 250-250-65 MG CPLT Acetaminophen, Aspirin, Caffeine	24385036571	$0.0648 per EA	-0.15%	Generic OTC	—	AmerisourceBergen
MIGRAINE FORMULA CAPLET Acetaminophen, Aspirin, Caffeine	24385036578	$0.0648 per EA	-0.15%	Generic OTC	—	AmerisourceBergen
GNP HEADACHE RELIEF CAPLET Acetaminophen, Aspirin, Caffeine	46122069078	$0.0648 per EA	-0.15%	Generic OTC	—	AmerisourceBergen
HEADACHE RLF 250-250-65 MG CPLT Acetaminophen, Aspirin, Caffeine	70000006601	$0.0648 per EA	-0.15%	Generic OTC	—	Cardinal Health
HEADACHE RELIEF CAPLET Acetaminophen, Aspirin, Caffeine	70000014601	$0.0648 per EA	-0.15%	Generic OTC	—	Cardinal Health
MIGRAINE 250-250-65 MG CPLT Acetaminophen, Aspirin, Caffeine	70000024701	$0.0648 per EA	-0.15%	Generic OTC	—	Cardinal Health
MIGRAINE 250-250-65 MG CPLT Acetaminophen, Aspirin, Caffeine	70000024702	$0.0648 per EA	-0.15%	Generic OTC	—	Cardinal Health
MIGRAINE 250-250-65 MG GELTAB acetaminophen, aspirin, caffeine	70000061101	$0.0648 per EA	-0.15%	Generic OTC	—	Cardinal Health
FT MIGRAINE 250-250-65 MG CPLT Acetaminophen, Aspirin, Caffeine	70677113301	$0.0648 per EA	-0.15%	Generic OTC	—	Strategic Sourcing Services LLC
QC HEADACHE RELIEF TABLET Acetaminophen, Aspirin and caffeine	63868048501	$0.0629 per EA	—	Generic OTC	—	Chain Drug Marketing Association
TENSION HEADACHE CAPLET Acetaminophen, Caffeine	70000015901	$0.0622 per EA	-2.38%	Generic OTC	—	Cardinal Health
TENSION HEADACHE CAPLET Acetaminophen, Caffeine	70000015902	$0.0622 per EA	-2.38%	Generic OTC	—	Cardinal Health
EXTRA PAIN RELIEF CAPLET ACETAMINOPHEN, ASPIRIN AND CAFFEINE	49483037000	$0.0621 per EA	—	Generic OTC	—	Time-Cap Labs Inc.
BACK-BODY PAIN 500-32.5 MG CPLT Aspirin, Caffeine	70000012702	$0.0422 per EA	—	Generic OTC	—	Cardinal Health

Follow this class across the site

These links connect the therapeutic class page to the specific suppliers, markets, and trend surfaces that help users keep exploring.

Top supplier

Haleon US Holdings LLC manufacturer profile

Review the supplier with the strongest product footprint inside this therapeutic class.

Lead market

Theophylline market page

Move from the therapeutic class into the molecule that appears most often in this class-specific portfolio.

Trend hub

Latest trend hub

Compare this class against the rest of the weekly NADAC trend surface.

Guide

Understanding NADAC pricing

Use the explainer when you need a plain-English refresher on how these class-level numbers are published and interpreted.

Frequently Asked Questions

How many drugs are in the Methylxanthine class?

The Methylxanthine class contains 122 NDCs from 47 manufacturers — 103 generic and 19 brand products.

What is the average price of Methylxanthine drugs?

The average NADAC for the Methylxanthine class is $1.1200 per unit across 122 NDCs.

Is generic cheaper than brand in the Methylxanthine class?

Among products priced per EA, the average generic NADAC in this class is $0.8380, versus $1.9440 for brand — brand products average about 2.3× the generic price.

Which manufacturers make Methylxanthine drugs?

47 manufacturers make drugs in the Methylxanthine class. Ranked by number of NDCs, the largest are Haleon US Holdings LLC (14), Cardinal Health (9), Actavis Pharma, Inc. (7), Lannett Company Inc. (5), Westminster Pharmaceuticals LLC (5).

How has Methylxanthine pricing changed recently?

Over the past 7 days, 17 NDCs in this class rose and 67 fell, with a class-wide average change of -1.1%.