Product Information
DIPHENHYDRAMINE 12.5 MG/5 ML is a generic product labeled by Rising Pharma Holdings Inc., priced at $0.0192 per ML under NDC 57237030512. Its NADAC has been published 180 times since Apr 26, 2023.
Strength
12.5 mg/5mL
Manufacturer
Rising Pharma Holdings Inc.NDC
57237030512
Classification
Generic
Dosage Form
LIQUID
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
DIPHENHYDRAMINE HYDROCHLORIDEApproval Type
OTC MONOGRAPH DRUG
FDA Application
M009.50On Market Since
12/19/2022
Pharmacological Classes
Price Statistics
The NADAC for DIPHENHYDRAMINE 12.5 MG/5 ML has been published 180 times since Apr 26, 2023, and over the history we have for it it has risen 22.5%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0192 per ML |
|---|---|
| All-time high | $0.0199 (Jul 15, 2026) |
| All-time low | $0.0147 (May 22, 2024) |
| 52-week high | $0.0199 |
| 52-week low | $0.0173 |
| Median price | $0.0171 |
| Average price | $0.0172 |
| Largest weekly change | +21.5% (Jun 19, 2024) |
| Weeks tracked | 180 |
| Tracking since | Apr 26, 2023 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 19% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Rising Pharma Holdings Inc. manufacturer profile
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Drug market
Diphenhydramine Hydrochloride market comparison
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Therapeutic class
Histamine-1 Receptor Antagonist class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of DIPHENHYDRAMINE 12.5 MG/5 ML?
The current National Average Drug Acquisition Cost (NADAC) for DIPHENHYDRAMINE 12.5 MG/5 ML, manufactured by Rising Pharma Holdings Inc., is $0.0192 per ML (NDC 57237030512), effective Sep 30, 2026.
How has the price of DIPHENHYDRAMINE 12.5 MG/5 ML changed over time?
Over the history we have for it, the NADAC for DIPHENHYDRAMINE 12.5 MG/5 ML has risen 22.5%. It has been tracked across 180 weekly CMS publications since Apr 26, 2023.
What are the highest and lowest recorded NADAC prices for DIPHENHYDRAMINE 12.5 MG/5 ML?
Since Apr 26, 2023, the NADAC for DIPHENHYDRAMINE 12.5 MG/5 ML has ranged from a low of $0.0147 (May 22, 2024) to a high of $0.0199 (Jul 15, 2026), with a median of $0.0171 per ML.
Are there cheaper alternatives to DIPHENHYDRAMINE 12.5 MG/5 ML?
Yes. 2 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, QC CHILD ALLERGY 12.5 MG/5 ML, is $0.0155 per ML — about 19% below DIPHENHYDRAMINE 12.5 MG/5 ML.
Who manufactures DIPHENHYDRAMINE 12.5 MG/5 ML?
DIPHENHYDRAMINE 12.5 MG/5 ML (NDC 57237030512) is labeled by Rising Pharma Holdings Inc., and CMS classifies it as a generic product.