Product Information
BUTORPHANOL 10 MG/ML SPRAY is a generic product labeled by Apotex Corp., priced at $15.4598 per ML under NDC 60505081301. Its NADAC has been published 671 times since Nov 28, 2013.
FDA first approved this application on Dec 4, 2002. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
10 mg/mL
Manufacturer
Apotex Corp.NDC
60505081301
Classification
Generic
Dosage Form
SPRAY
Route
NASAL
Effective Date
9/23/2026
Active Ingredients
BUTORPHANOL TARTRATEApproval Type
Generic (ANDA)
FDA Application
ANDA075499FDA Approved
12/4/2002
TE Code
AB
On Market Since
12/4/2002
Pharmacological Classes
Price Statistics
The NADAC for BUTORPHANOL 10 MG/ML SPRAY has been published 671 times since Nov 28, 2013, and over the history we have for it it has risen 203.5%. The table below summarizes its recorded NADAC range and movement.
| Current price | $15.4598 per ML |
|---|---|
| All-time high | $16.0178 (Nov 12, 2025) |
| All-time low | $5.0940 (Nov 28, 2013) |
| 52-week high | $16.0178 |
| 52-week low | $14.5081 |
| Median price | $13.6562 |
| Average price | $13.3519 |
| Largest weekly change | +67.0% (Mar 19, 2014) |
| Weeks tracked | 671 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Apotex Corp. manufacturer profile
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Drug market
Butorphanol Tartrate market comparison
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Therapeutic class
Opioid Agonist/Antagonist class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of BUTORPHANOL 10 MG/ML SPRAY?
The current National Average Drug Acquisition Cost (NADAC) for BUTORPHANOL 10 MG/ML SPRAY, manufactured by Apotex Corp., is $15.4598 per ML (NDC 60505081301), effective Sep 30, 2026.
How has the price of BUTORPHANOL 10 MG/ML SPRAY changed over time?
Over the history we have for it, the NADAC for BUTORPHANOL 10 MG/ML SPRAY has risen 203.5%. It has been tracked across 671 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for BUTORPHANOL 10 MG/ML SPRAY?
Since Nov 28, 2013, the NADAC for BUTORPHANOL 10 MG/ML SPRAY has ranged from a low of $5.0940 (Nov 28, 2013) to a high of $16.0178 (Nov 12, 2025), with a median of $13.6562 per ML.
Are there cheaper alternatives to BUTORPHANOL 10 MG/ML SPRAY?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as BUTORPHANOL 10 MG/ML SPRAY in a comparable dosage form, but none are currently priced below it.
Who manufactures BUTORPHANOL 10 MG/ML SPRAY?
BUTORPHANOL 10 MG/ML SPRAY (NDC 60505081301) is labeled by Apotex Corp., and CMS classifies it as a generic product.