Product Information
LYLLANA 0.0375 MG PATCH is a generic product labeled by Amneal Pharmaceuticals LLC, priced at $8.2623 per EA under NDC 65162014808. Its NADAC has been published 296 times since Feb 3, 2021.
FDA first approved this application on Sep 28, 2020. Its Orange Book therapeutic-equivalence code is AB3 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.0375 mg/d
Manufacturer
Amneal Pharmaceuticals LLCNDC
65162014808
Classification
Generic
Dosage Form
PATCH, EXTENDED RELEASE
Route
TRANSDERMAL
Effective Date
9/23/2026
Active Ingredients
ESTRADIOLApproval Type
Generic (ANDA)
FDA Application
ANDA211396FDA Approved
9/28/2020
TE Code
AB3
On Market Since
9/30/2020
Pharmacological Classes
Price Statistics
The NADAC for LYLLANA 0.0375 MG PATCH has been published 296 times since Feb 3, 2021, and over the history we have for it it has risen 15.8%. The table below summarizes its recorded NADAC range and movement.
| Current price | $8.2623 per EA |
|---|---|
| All-time high | $10.3341 (Apr 13, 2022) |
| All-time low | $5.3236 (Nov 20, 2024) |
| 52-week high | $8.2623 |
| 52-week low | $6.6398 |
| Median price | $6.9638 |
| Average price | $7.1092 |
| Largest weekly change | +29.5% (Mar 23, 2022) |
| Weeks tracked | 296 |
| Tracking since | Feb 3, 2021 |
Generic Alternatives
The matcher finds 4 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Amneal Pharmaceuticals LLC manufacturer profile
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Drug market
Estradiol market comparison
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Therapeutic class
Estrogen class view
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Trend hub
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Guide
Understanding NADAC pricing
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Frequently asked questions
What is the NADAC price of LYLLANA 0.0375 MG PATCH?
The current National Average Drug Acquisition Cost (NADAC) for LYLLANA 0.0375 MG PATCH, manufactured by Amneal Pharmaceuticals LLC, is $8.2623 per EA (NDC 65162014808), effective Sep 30, 2026.
How has the price of LYLLANA 0.0375 MG PATCH changed over time?
Over the history we have for it, the NADAC for LYLLANA 0.0375 MG PATCH has risen 15.8%. It has been tracked across 296 weekly CMS publications since Feb 3, 2021.
What are the highest and lowest recorded NADAC prices for LYLLANA 0.0375 MG PATCH?
Since Feb 3, 2021, the NADAC for LYLLANA 0.0375 MG PATCH has ranged from a low of $5.3236 (Nov 20, 2024) to a high of $10.3341 (Apr 13, 2022), with a median of $6.9638 per EA.
Are there cheaper alternatives to LYLLANA 0.0375 MG PATCH?
4 manufacturers publish a NADAC-priced product with the same active ingredient and strength as LYLLANA 0.0375 MG PATCH in a comparable dosage form, but none are currently priced below it.
Who manufactures LYLLANA 0.0375 MG PATCH?
LYLLANA 0.0375 MG PATCH (NDC 65162014808) is labeled by Amneal Pharmaceuticals LLC, and CMS classifies it as a generic product.