Product Information
ESTRADIOL 0.0375 MG PATCH(2/WK) is a generic product labeled by Zydus Pharmaceuticals (USA) Inc., priced at $8.2623 per EA under NDC 70710119208. Its NADAC has been published 151 times since Nov 15, 2023.
FDA first approved this application on Dec 1, 2022. Its Orange Book therapeutic-equivalence code is AB1 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.0375 mg/d
Manufacturer
Zydus Pharmaceuticals (USA) Inc.NDC
70710119208
Classification
Generic
Dosage Form
PATCH, EXTENDED RELEASE
Route
TRANSDERMAL
Effective Date
9/23/2026
Active Ingredients
ESTRADIOLApproval Type
Generic (ANDA)
FDA Application
ANDA206241FDA Approved
12/1/2022
TE Code
AB1
On Market Since
4/13/2023
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.0375 MG PATCH(2/WK) has been published 151 times since Nov 15, 2023, and over the history we have for it it has risen 23.3%. The table below summarizes its recorded NADAC range and movement.
| Current price | $8.2623 per EA |
|---|---|
| All-time high | $8.2623 (Sep 30, 2026) |
| All-time low | $5.3236 (Nov 20, 2024) |
| 52-week high | $8.2623 |
| 52-week low | $6.6398 |
| Median price | $6.9326 |
| Average price | $6.8496 |
| Largest weekly change | +26.0% (Aug 21, 2024) |
| Weeks tracked | 151 |
| Tracking since | Nov 15, 2023 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Zydus Pharmaceuticals (USA) Inc. manufacturer profile
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Drug market
Estradiol market comparison
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Therapeutic class
Estrogen class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.0375 MG PATCH(2/WK)?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.0375 MG PATCH(2/WK), manufactured by Zydus Pharmaceuticals (USA) Inc., is $8.2623 per EA (NDC 70710119208), effective Sep 30, 2026.
How has the price of ESTRADIOL 0.0375 MG PATCH(2/WK) changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.0375 MG PATCH(2/WK) has risen 23.3%. It has been tracked across 151 weekly CMS publications since Nov 15, 2023.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.0375 MG PATCH(2/WK)?
Since Nov 15, 2023, the NADAC for ESTRADIOL 0.0375 MG PATCH(2/WK) has ranged from a low of $5.3236 (Nov 20, 2024) to a high of $8.2623 (Sep 30, 2026), with a median of $6.9326 per EA.
Are there cheaper alternatives to ESTRADIOL 0.0375 MG PATCH(2/WK)?
3 manufacturers publish a NADAC-priced product with the same active ingredient and strength as ESTRADIOL 0.0375 MG PATCH(2/WK) in a comparable dosage form, but none are currently priced below it.
Who manufactures ESTRADIOL 0.0375 MG PATCH(2/WK)?
ESTRADIOL 0.0375 MG PATCH(2/WK) (NDC 70710119208) is labeled by Zydus Pharmaceuticals (USA) Inc., and CMS classifies it as a generic product.