Product Information
CLIMARA 0.0375 MG/DAY PATCH is a brand product labeled by Bayer HealthCare Pharmaceuticals Inc., priced at $18.3023 per EA under NDC 50419045604. Its NADAC has been published 527 times since Nov 28, 2013.
The High Outlier badge above means this manufacturer's average price in the Estradiol market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
Strength
.0375 mg/d
Manufacturer
Bayer HealthCare Pharmaceuticals Inc.NDC
50419045604
Classification
Brand
Dosage Form
PATCH
Route
TRANSDERMAL
Last Updated
6/17/2026
Active Ingredients
ESTRADIOLApproval Type
New Drug (NDA)
FDA Application
NDA020375On Market Since
5/27/2003
Pharmacological Classes
Price Statistics
The NADAC for CLIMARA 0.0375 MG/DAY PATCH has been published 527 times since Nov 28, 2013, and over the history we have for it it has declined 20.6%. The table below summarizes its recorded NADAC range and movement.
| Current price | $18.3023 per EA |
|---|---|
| All-time high | $36.4199 (Mar 15, 2023) |
| All-time low | $18.2868 (Jan 21, 2026) |
| 52-week high | $18.3405 |
| 52-week low | $18.2868 |
| Median price | $27.3629 |
| Average price | $27.8609 |
| Largest weekly change | -49.6% (Jun 19, 2024) |
| Weeks tracked | 527 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
The matcher finds 3 NADAC-published products sharing this drug's active ingredient, strength, and dosage form across 3 manufacturers (up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 57% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Frequently asked questions
What is the NADAC price of CLIMARA 0.0375 MG/DAY PATCH?
The current National Average Drug Acquisition Cost (NADAC) for CLIMARA 0.0375 MG/DAY PATCH, manufactured by Bayer HealthCare Pharmaceuticals Inc., is $18.3023 per EA (NDC 50419045604), effective Jun 24, 2026.
How has the price of CLIMARA 0.0375 MG/DAY PATCH changed over time?
Over the history we have for it, the NADAC for CLIMARA 0.0375 MG/DAY PATCH has declined 20.6%. It has been tracked across 527 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for CLIMARA 0.0375 MG/DAY PATCH?
Since Nov 28, 2013, the NADAC for CLIMARA 0.0375 MG/DAY PATCH has ranged from a low of $18.2868 (Jan 21, 2026) to a high of $36.4199 (Mar 15, 2023), with a median of $27.3629 per EA.
Are there cheaper alternatives to CLIMARA 0.0375 MG/DAY PATCH?
Yes. 3 NADAC-published products share the same active ingredient, strength, and dosage form. The lowest-priced option, DOTTI 0.0375 MG PATCH, is $7.8091 per EA — about 57% below CLIMARA 0.0375 MG/DAY PATCH.
Who manufactures CLIMARA 0.0375 MG/DAY PATCH?
CLIMARA 0.0375 MG/DAY PATCH (NDC 50419045604) is labeled by Bayer HealthCare Pharmaceuticals Inc., and CMS classifies it as a brand product.
Related Drugs
Same classification