Product Information
CLIMARA 0.0375 MG/DAY PATCH is a brand product labeled by Bayer HealthCare Pharmaceuticals Inc., priced at $18.2986 per EA under NDC 50419045604. Its NADAC has been published 535 times since Nov 28, 2013.
FDA first approved this application on Dec 22, 1994. Its Orange Book therapeutic-equivalence code is AB2 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.0375 mg/d
Manufacturer
Bayer HealthCare Pharmaceuticals Inc.NDC
50419045604
Classification
Brand
Dosage Form
PATCH
Route
TRANSDERMAL
Effective Date
8/19/2026
Active Ingredients
ESTRADIOLApproval Type
New Drug (NDA)
FDA Application
NDA020375FDA Approved
12/22/1994
TE Code
AB2
On Market Since
5/27/2003
Pharmacological Classes
Price Statistics
The NADAC for CLIMARA 0.0375 MG/DAY PATCH has been published 535 times since Nov 28, 2013, and over the history we have for it it has declined 20.6%. The table below summarizes its recorded NADAC range and movement.
| Current price | $18.2986 per EA |
|---|---|
| All-time high | $36.4199 (Mar 15, 2023) |
| All-time low | $18.2868 (Jan 21, 2026) |
| 52-week high | $18.3405 |
| 52-week low | $18.2868 |
| Median price | $27.3629 |
| Average price | $27.7179 |
| Largest weekly change | -49.6% (Jun 19, 2024) |
| Weeks tracked | 535 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 55% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of CLIMARA 0.0375 MG/DAY PATCH?
The current National Average Drug Acquisition Cost (NADAC) for CLIMARA 0.0375 MG/DAY PATCH, manufactured by Bayer HealthCare Pharmaceuticals Inc., is $18.2986 per EA (NDC 50419045604), effective Aug 19, 2026.
How has the price of CLIMARA 0.0375 MG/DAY PATCH changed over time?
Over the history we have for it, the NADAC for CLIMARA 0.0375 MG/DAY PATCH has declined 20.6%. It has been tracked across 535 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for CLIMARA 0.0375 MG/DAY PATCH?
Since Nov 28, 2013, the NADAC for CLIMARA 0.0375 MG/DAY PATCH has ranged from a low of $18.2868 (Jan 21, 2026) to a high of $36.4199 (Mar 15, 2023), with a median of $27.3629 per EA.
Are there cheaper alternatives to CLIMARA 0.0375 MG/DAY PATCH?
Yes. 3 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, DOTTI 0.0375 MG PATCH, is $8.2278 per EA — about 55% below CLIMARA 0.0375 MG/DAY PATCH.
Who manufactures CLIMARA 0.0375 MG/DAY PATCH?
CLIMARA 0.0375 MG/DAY PATCH (NDC 50419045604) is labeled by Bayer HealthCare Pharmaceuticals Inc., and CMS classifies it as a brand product.