Product Information
DOTTI 0.0375 MG PATCH is a generic product labeled by Amneal Pharmaceuticals LLC, priced at $8.2623 per EA under NDC 65162099208. Its NADAC has been published 378 times since Jul 10, 2019.
FDA first approved this application on Feb 4, 2019. Its Orange Book therapeutic-equivalence code is AB1 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.0375 mg/d
Manufacturer
Amneal Pharmaceuticals LLCNDC
65162099208
Classification
Generic
Dosage Form
PATCH, EXTENDED RELEASE
Route
TRANSDERMAL
Effective Date
9/23/2026
Active Ingredients
ESTRADIOLApproval Type
Generic (ANDA)
FDA Application
ANDA211293FDA Approved
2/4/2019
TE Code
AB1
On Market Since
2/4/2019
Pharmacological Classes
Price Statistics
The NADAC for DOTTI 0.0375 MG PATCH has been published 378 times since Jul 10, 2019, and over the history we have for it it has declined 3.0%. The table below summarizes its recorded NADAC range and movement.
| Current price | $8.2623 per EA |
|---|---|
| All-time high | $10.3341 (Apr 13, 2022) |
| All-time low | $5.3236 (Nov 20, 2024) |
| 52-week high | $8.2623 |
| 52-week low | $6.6398 |
| Median price | $7.1054 |
| Average price | $7.3287 |
| Largest weekly change | +29.5% (Mar 23, 2022) |
| Weeks tracked | 378 |
| Tracking since | Jul 10, 2019 |
Generic Alternatives
The matcher finds 4 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Amneal Pharmaceuticals LLC manufacturer profile
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Drug market
Estradiol market comparison
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Therapeutic class
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Trend hub
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Guide
Understanding NADAC pricing
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Frequently asked questions
What is the NADAC price of DOTTI 0.0375 MG PATCH?
The current National Average Drug Acquisition Cost (NADAC) for DOTTI 0.0375 MG PATCH, manufactured by Amneal Pharmaceuticals LLC, is $8.2623 per EA (NDC 65162099208), effective Sep 30, 2026.
How has the price of DOTTI 0.0375 MG PATCH changed over time?
Over the history we have for it, the NADAC for DOTTI 0.0375 MG PATCH has declined 3.0%. It has been tracked across 378 weekly CMS publications since Jul 10, 2019.
What are the highest and lowest recorded NADAC prices for DOTTI 0.0375 MG PATCH?
Since Jul 10, 2019, the NADAC for DOTTI 0.0375 MG PATCH has ranged from a low of $5.3236 (Nov 20, 2024) to a high of $10.3341 (Apr 13, 2022), with a median of $7.1054 per EA.
Are there cheaper alternatives to DOTTI 0.0375 MG PATCH?
4 manufacturers publish a NADAC-priced product with the same active ingredient and strength as DOTTI 0.0375 MG PATCH in a comparable dosage form, but none are currently priced below it.
Who manufactures DOTTI 0.0375 MG PATCH?
DOTTI 0.0375 MG PATCH (NDC 65162099208) is labeled by Amneal Pharmaceuticals LLC, and CMS classifies it as a generic product.