Product Information
ESTRADIOL 0.0375 MG PATCH(1/WK) is a generic product labeled by Sandoz Inc., priced at $11.9304 per EA under NDC 00781712254. Its NADAC has been published 413 times since Nov 7, 2018.
FDA first approved this application on Dec 22, 1994. Its Orange Book therapeutic-equivalence code is AB2 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.0375 mg/d
Manufacturer
Sandoz Inc.NDC
00781712254
Classification
Generic
Dosage Form
PATCH
Route
TRANSDERMAL
Effective Date
9/23/2026
Active Ingredients
ESTRADIOLApproval Type
Authorized Generic (NDA)
FDA Application
NDA020375FDA Approved
12/22/1994
TE Code
AB2
On Market Since
5/27/2003
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.0375 MG PATCH(1/WK) has been published 413 times since Nov 7, 2018, and over the history we have for it it has declined 18.1%. The table below summarizes its recorded NADAC range and movement.
| Current price | $11.9304 per EA |
|---|---|
| All-time high | $16.1747 (Mar 16, 2022) |
| All-time low | $9.4369 (Oct 18, 2023) |
| 52-week high | $12.2291 |
| 52-week low | $10.8148 |
| Median price | $13.2410 |
| Average price | $12.9723 |
| Largest weekly change | +40.2% (Nov 22, 2023) |
| Weeks tracked | 413 |
| Tracking since | Nov 7, 2018 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 31% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
Use these direct paths to move from a single NDC into the surrounding market, manufacturer, class, and trend context.
Manufacturer
Sandoz Inc. manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Estradiol market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Estrogen class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.0375 MG PATCH(1/WK)?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.0375 MG PATCH(1/WK), manufactured by Sandoz Inc., is $11.9304 per EA (NDC 00781712254), effective Sep 30, 2026.
How has the price of ESTRADIOL 0.0375 MG PATCH(1/WK) changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.0375 MG PATCH(1/WK) has declined 18.1%. It has been tracked across 413 weekly CMS publications since Nov 7, 2018.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.0375 MG PATCH(1/WK)?
Since Nov 7, 2018, the NADAC for ESTRADIOL 0.0375 MG PATCH(1/WK) has ranged from a low of $9.4369 (Oct 18, 2023) to a high of $16.1747 (Mar 16, 2022), with a median of $13.2410 per EA.
Are there cheaper alternatives to ESTRADIOL 0.0375 MG PATCH(1/WK)?
Yes. 3 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, LYLLANA 0.0375 MG PATCH, is $8.2623 per EA — about 31% below ESTRADIOL 0.0375 MG PATCH(1/WK).
Who manufactures ESTRADIOL 0.0375 MG PATCH(1/WK)?
ESTRADIOL 0.0375 MG PATCH(1/WK) (NDC 00781712254) is labeled by Sandoz Inc., and CMS classifies it as a generic product.