Product Information
NAPROXEN 375 MG TABLET is a generic product labeled by Amneal Pharmaceuticals LLC, priced at $0.0588 per EA under NDC 65162018950. Its NADAC has been published 598 times since Apr 1, 2015.
FDA first approved this application on Dec 18, 2001. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
375 mg/1
Manufacturer
Amneal Pharmaceuticals LLCNDC
65162018950
Classification
Generic
Dosage Form
TABLET
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
NAPROXENApproval Type
Generic (ANDA)
FDA Application
ANDA075927FDA Approved
12/18/2001
TE Code
AB
On Market Since
2/18/2010
Pharmacological Classes
Price Statistics
The NADAC for NAPROXEN 375 MG TABLET has been published 598 times since Apr 1, 2015, and over the history we have for it it has risen 35.2%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0588 per EA |
|---|---|
| All-time high | $0.0808 (Jun 16, 2021) |
| All-time low | $0.0435 (Apr 1, 2015) |
| 52-week high | $0.0601 |
| 52-week low | $0.0561 |
| Median price | $0.0633 |
| Average price | $0.0651 |
| Largest weekly change | +36.8% (Apr 22, 2015) |
| Weeks tracked | 598 |
| Tracking since | Apr 1, 2015 |
Generic Alternatives
The matcher finds 10 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 3% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Amneal Pharmaceuticals LLC manufacturer profile
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Drug market
Naproxen market comparison
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Therapeutic class
Nonsteroidal Anti-inflammatory Drug class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of NAPROXEN 375 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for NAPROXEN 375 MG TABLET, manufactured by Amneal Pharmaceuticals LLC, is $0.0588 per EA (NDC 65162018950), effective Sep 30, 2026.
How has the price of NAPROXEN 375 MG TABLET changed over time?
Over the history we have for it, the NADAC for NAPROXEN 375 MG TABLET has risen 35.2%. It has been tracked across 598 weekly CMS publications since Apr 1, 2015.
What are the highest and lowest recorded NADAC prices for NAPROXEN 375 MG TABLET?
Since Apr 1, 2015, the NADAC for NAPROXEN 375 MG TABLET has ranged from a low of $0.0435 (Apr 1, 2015) to a high of $0.0808 (Jun 16, 2021), with a median of $0.0633 per EA.
Are there cheaper alternatives to NAPROXEN 375 MG TABLET?
Yes. 10 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, NAPROXEN 375 MG TABLET, is $0.0573 per EA — about 3% below NAPROXEN 375 MG TABLET.
Who manufactures NAPROXEN 375 MG TABLET?
NAPROXEN 375 MG TABLET (NDC 65162018950) is labeled by Amneal Pharmaceuticals LLC, and CMS classifies it as a generic product.