Product Information
PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION is a generic product labeled by Amneal Pharmaceuticals LLC, priced at $0.0510 per ML under NDC 65162068086. Its NADAC has been published 238 times since May 6, 2020.
The High Outlier badge above means this manufacturer's average price in the Promethazine Hydrochloride and Dextromethorphan Hydrobromide market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION
Promethazine Hydrochloride and Dextromethorphan HydrobromideStrength
15; 6.25 mg/5mL; mg/5mL
Manufacturer
Amneal Pharmaceuticals LLCNDC
65162068086
Classification
Generic
Dosage Form
SOLUTION
Route
ORAL
Last Updated
7/23/2025
Active Ingredients
DEXTROMETHORPHAN HYDROBROMIDE; PROMETHAZINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA090575On Market Since
3/4/2011
Pharmacological Classes
Price Statistics
The NADAC for PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION has been published 238 times since May 6, 2020, and over the history we have for it it has risen 148.7%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0510 per ML |
|---|---|
| All-time high | $0.0686 (May 11, 2022) |
| All-time low | $0.0205 (May 6, 2020) |
| 52-week high | $0.0512 |
| 52-week low | $0.0510 |
| Median price | $0.0537 |
| Average price | $0.0545 |
| Largest weekly change | +212.4% (Jan 19, 2022) |
| Weeks tracked | 238 |
| Tracking since | May 6, 2020 |
Generic Alternatives
The matcher finds 6 NADAC-published products sharing this drug's active ingredient, strength, and dosage form across 6 manufacturers (up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 25% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Frequently asked questions
What is the NADAC price of PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION?
The current National Average Drug Acquisition Cost (NADAC) for PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION, manufactured by Amneal Pharmaceuticals LLC, is $0.0510 per ML (NDC 65162068086), effective Jun 24, 2026.
How has the price of PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION changed over time?
Over the history we have for it, the NADAC for PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION has risen 148.7%. It has been tracked across 238 weekly CMS publications since May 6, 2020.
What are the highest and lowest recorded NADAC prices for PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION?
Since May 6, 2020, the NADAC for PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION has ranged from a low of $0.0205 (May 6, 2020) to a high of $0.0686 (May 11, 2022), with a median of $0.0537 per ML.
Are there cheaper alternatives to PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION?
Yes. 6 NADAC-published products share the same active ingredient, strength, and dosage form. The lowest-priced option, PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION, is $0.0383 per ML — about 25% below PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION.
Who manufactures PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION?
PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION (NDC 65162068086) is labeled by Amneal Pharmaceuticals LLC, and CMS classifies it as a generic product.
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