Product Information
PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION is a generic product labeled by Amneal Pharmaceuticals LLC, priced at $0.0510 per ML under NDC 65162068086. Its NADAC has been published 241 times since May 6, 2020.
FDA first approved this application on Feb 8, 2011. Its Orange Book therapeutic-equivalence code is AA.
The High Outlier badge above means this manufacturer's average price in the Promethazine Hydrochloride and Dextromethorphan Hydrobromide market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION
Promethazine Hydrochloride and Dextromethorphan HydrobromideStrength
15; 6.25 mg/5mL; mg/5mL
Manufacturer
Amneal Pharmaceuticals LLCNDC
65162068086
Classification
Generic
Dosage Form
SOLUTION
Route
ORAL
Effective Date
7/23/2025
Active Ingredients
DEXTROMETHORPHAN HYDROBROMIDE; PROMETHAZINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA090575FDA Approved
2/8/2011
TE Code
AA
On Market Since
3/4/2011
Pharmacological Classes
Price Statistics
The NADAC for PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION has been published 241 times since May 6, 2020, and over the history we have for it it has risen 148.7%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0510 per ML |
|---|---|
| All-time high | $0.0686 (May 11, 2022) |
| All-time low | $0.0205 (May 6, 2020) |
| 52-week high | $0.0510 |
| 52-week low | $0.0510 |
| Median price | $0.0537 |
| Average price | $0.0545 |
| Largest weekly change | +212.4% (Jan 19, 2022) |
| Weeks tracked | 241 |
| Tracking since | May 6, 2020 |
1W
N/A
1M
N/A
3M
0.0%
6M
0.0%
1Y
0.0%
3Y
-15.8%
5Y
+148.7%
All
+148.7%
Last surveyed Jul 15, 2026 — this NDC no longer appears in the current weekly NADAC file.
Generic Alternatives
The matcher finds 5 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 25% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION?
The current National Average Drug Acquisition Cost (NADAC) for PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION, manufactured by Amneal Pharmaceuticals LLC, is $0.0510 per ML (NDC 65162068086), effective Jul 15, 2026.
How has the price of PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION changed over time?
Over the history we have for it, the NADAC for PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION has risen 148.7%. It has been tracked across 241 weekly CMS publications since May 6, 2020.
What are the highest and lowest recorded NADAC prices for PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION?
Since May 6, 2020, the NADAC for PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION has ranged from a low of $0.0205 (May 6, 2020) to a high of $0.0686 (May 11, 2022), with a median of $0.0537 per ML.
Are there cheaper alternatives to PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION?
Yes. 5 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION, is $0.0384 per ML — about 25% below PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION.
Who manufactures PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION?
PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION (NDC 65162068086) is labeled by Amneal Pharmaceuticals LLC, and CMS classifies it as a generic product.