Product Information
PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION is a generic product labeled by Amneal Pharmaceuticals LLC, priced at $0.0510 per ML under NDC 65162068086. Its NADAC has been published 241 times since May 6, 2020.
FDA first approved this application on Feb 8, 2011. Its Orange Book therapeutic-equivalence code is AA.
The High Outlier badge above means this manufacturer's average price in the Promethazine Hydrochloride and Dextromethorphan Hydrobromide market falls above Q3 + 1.5·IQR across all competing manufacturers. We only apply this flag in markets with four or more competitors. Full definition: glossary → outlier.
PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION
Promethazine Hydrochloride and Dextromethorphan HydrobromideStrength
15; 6.25 mg/5mL; mg/5mL
Manufacturer
Amneal Pharmaceuticals LLCNDC
65162068086
Classification
Generic
Dosage Form
SOLUTION
Route
ORAL
Effective Date
7/23/2025
Active Ingredients
DEXTROMETHORPHAN HYDROBROMIDE; PROMETHAZINE HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA090575FDA Approved
2/8/2011
TE Code
AA
On Market Since
3/4/2011
Pharmacological Classes
Price Statistics
The NADAC for PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION has been published 241 times since May 6, 2020, and over the history we have for it it has risen 148.7%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.0510 per ML |
|---|---|
| All-time high | $0.0686 (May 11, 2022) |
| All-time low | $0.0205 (May 6, 2020) |
| 52-week high | $0.0510 |
| 52-week low | $0.0510 |
| Median price | $0.0537 |
| Average price | $0.0545 |
| Largest weekly change | +212.4% (Jan 19, 2022) |
| Weeks tracked | 241 |
| Tracking since | May 6, 2020 |
1W
N/A
1M
N/A
3M
0.0%
6M
0.0%
1Y
0.0%
3Y
-15.5%
5Y
+148.7%
All
+148.7%
Last surveyed Jul 15, 2026 — this NDC no longer appears in the current weekly NADAC file.
Generic Alternatives
The matcher finds 5 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 23% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
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Manufacturer
Amneal Pharmaceuticals LLC manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
Promethazine Hydrochloride and Dextromethorphan Hydrobromide market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Phenothiazine class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION?
The current National Average Drug Acquisition Cost (NADAC) for PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION, manufactured by Amneal Pharmaceuticals LLC, is $0.0510 per ML (NDC 65162068086), effective Jul 15, 2026.
How has the price of PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION changed over time?
Over the history we have for it, the NADAC for PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION has risen 148.7%. It has been tracked across 241 weekly CMS publications since May 6, 2020.
What are the highest and lowest recorded NADAC prices for PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION?
Since May 6, 2020, the NADAC for PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION has ranged from a low of $0.0205 (May 6, 2020) to a high of $0.0686 (May 11, 2022), with a median of $0.0537 per ML.
Are there cheaper alternatives to PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION?
Yes. 5 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION, is $0.0390 per ML — about 23% below PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION.
Who manufactures PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION?
PROMETHAZINE-DM 6.25-15 MG/5 ML SOLUTION (NDC 65162068086) is labeled by Amneal Pharmaceuticals LLC, and CMS classifies it as a generic product.