Product Information
VIVELLE-DOT 0.025 MG PATCH is a brand product labeled by Sandoz Inc., priced at $18.3787 per EA under NDC 66758014583. Its NADAC has been published 76 times since Apr 23, 2025.
FDA first approved this application on Jan 8, 1999. Its Orange Book therapeutic-equivalence code is AB1 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.025 mg/d
Manufacturer
Sandoz Inc.NDC
66758014583
Classification
Brand
Dosage Form
PATCH, EXTENDED RELEASE
Route
TRANSDERMAL
Effective Date
9/23/2026
Active Ingredients
ESTRADIOLApproval Type
New Drug (NDA)
FDA Application
NDA020538FDA Approved
1/8/1999
TE Code
AB1
On Market Since
1/8/1999
Pharmacological Classes
Price Statistics
The NADAC for VIVELLE-DOT 0.025 MG PATCH has been published 76 times since Apr 23, 2025, and over the history we have for it it has held within roughly two percent of its current level. The table below summarizes its recorded NADAC range and movement.
| Current price | $18.3787 per EA |
|---|---|
| All-time high | $18.4644 (Nov 12, 2025) |
| All-time low | $18.3283 (Apr 23, 2025) |
| 52-week high | $18.4644 |
| 52-week low | $18.3787 |
| Median price | $18.3996 |
| Average price | $18.4023 |
| Largest weekly change | +0.3% (Jul 23, 2025) |
| Weeks tracked | 76 |
| Tracking since | Apr 23, 2025 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 58% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Sandoz Inc. manufacturer profile
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Therapeutic class
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Trend hub
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of VIVELLE-DOT 0.025 MG PATCH?
The current National Average Drug Acquisition Cost (NADAC) for VIVELLE-DOT 0.025 MG PATCH, manufactured by Sandoz Inc., is $18.3787 per EA (NDC 66758014583), effective Sep 30, 2026.
How has the price of VIVELLE-DOT 0.025 MG PATCH changed over time?
Over the history we have for it, the NADAC for VIVELLE-DOT 0.025 MG PATCH has held within roughly two percent of its current level. It has been tracked across 76 weekly CMS publications since Apr 23, 2025.
What are the highest and lowest recorded NADAC prices for VIVELLE-DOT 0.025 MG PATCH?
Since Apr 23, 2025, the NADAC for VIVELLE-DOT 0.025 MG PATCH has ranged from a low of $18.3283 (Apr 23, 2025) to a high of $18.4644 (Nov 12, 2025), with a median of $18.3996 per EA.
Are there cheaper alternatives to VIVELLE-DOT 0.025 MG PATCH?
Yes. 2 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, ESTRADIOL 0.025 MG PATCH(2/WK), is $7.7577 per EA — about 58% below VIVELLE-DOT 0.025 MG PATCH.
Who manufactures VIVELLE-DOT 0.025 MG PATCH?
VIVELLE-DOT 0.025 MG PATCH (NDC 66758014583) is labeled by Sandoz Inc., and CMS classifies it as a brand product.