Product Information
ESTRADIOL 0.01% CREAM is a generic product labeled by Prasco Laboratories, priced at $0.4645 per GM under NDC 66993000210. Its NADAC has been published 237 times since Mar 23, 2022.
FDA first approved this application on Jul 15, 2021. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.1 mg/g
Manufacturer
Prasco LaboratoriesNDC
66993000210
Classification
Generic
Dosage Form
CREAM
Route
VAGINAL
Effective Date
9/23/2026
Active Ingredients
ESTRADIOLApproval Type
Generic (ANDA)
FDA Application
ANDA212313FDA Approved
7/15/2021
TE Code
AB
On Market Since
10/1/2021
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.01% CREAM has been published 237 times since Mar 23, 2022, and over the history we have for it it has declined 47.2%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.4645 per GM |
|---|---|
| All-time high | $0.8798 (Apr 13, 2022) |
| All-time low | $0.3692 (Nov 20, 2024) |
| 52-week high | $0.4696 |
| 52-week low | $0.3802 |
| Median price | $0.4927 |
| Average price | $0.5410 |
| Largest weekly change | -24.2% (Nov 20, 2024) |
| Weeks tracked | 237 |
| Tracking since | Mar 23, 2022 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Prasco Laboratories manufacturer profile
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Therapeutic class
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Trend hub
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Guide
Understanding NADAC pricing
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Frequently asked questions
What is the NADAC price of ESTRADIOL 0.01% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.01% CREAM, manufactured by Prasco Laboratories, is $0.4645 per GM (NDC 66993000210), effective Sep 30, 2026.
How has the price of ESTRADIOL 0.01% CREAM changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.01% CREAM has declined 47.2%. It has been tracked across 237 weekly CMS publications since Mar 23, 2022.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.01% CREAM?
Since Mar 23, 2022, the NADAC for ESTRADIOL 0.01% CREAM has ranged from a low of $0.3692 (Nov 20, 2024) to a high of $0.8798 (Apr 13, 2022), with a median of $0.4927 per GM.
Are there cheaper alternatives to ESTRADIOL 0.01% CREAM?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as ESTRADIOL 0.01% CREAM in a comparable dosage form, but none are currently priced below it.
Who manufactures ESTRADIOL 0.01% CREAM?
ESTRADIOL 0.01% CREAM (NDC 66993000210) is labeled by Prasco Laboratories, and CMS classifies it as a generic product.