Product Information
ESTRADIOL 0.01% CREAM is a generic product labeled by Prasco Laboratories, priced at $0.3888 per GM under NDC 66993000210. Its NADAC has been published 223 times since Mar 23, 2022.
Strength
.1 mg/g
Manufacturer
Prasco LaboratoriesNDC
66993000210
Classification
Generic
Dosage Form
CREAM
Route
VAGINAL
Last Updated
6/17/2026
Active Ingredients
ESTRADIOLApproval Type
Generic (ANDA)
FDA Application
ANDA212313On Market Since
10/1/2021
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.01% CREAM has been published 223 times since Mar 23, 2022, and over the history we have for it it has declined 55.8%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.3888 per GM |
|---|---|
| All-time high | $0.8798 (Apr 13, 2022) |
| All-time low | $0.3692 (Nov 20, 2024) |
| 52-week high | $0.4871 |
| 52-week low | $0.3861 |
| Median price | $0.5085 |
| Average price | $0.5492 |
| Largest weekly change | -24.2% (Nov 20, 2024) |
| Weeks tracked | 223 |
| Tracking since | Mar 23, 2022 |
Generic Alternatives
The matcher finds 1 NADAC-published product sharing this drug's active ingredient, strength, and dosage form across 1 manufacturer (up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.01% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.01% CREAM, manufactured by Prasco Laboratories, is $0.3888 per GM (NDC 66993000210), effective Jun 24, 2026.
How has the price of ESTRADIOL 0.01% CREAM changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.01% CREAM has declined 55.8%. It has been tracked across 223 weekly CMS publications since Mar 23, 2022.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.01% CREAM?
Since Mar 23, 2022, the NADAC for ESTRADIOL 0.01% CREAM has ranged from a low of $0.3692 (Nov 20, 2024) to a high of $0.8798 (Apr 13, 2022), with a median of $0.5085 per GM.
Are there cheaper alternatives to ESTRADIOL 0.01% CREAM?
1 NADAC-published product shares the same active ingredient, strength, and dosage form as ESTRADIOL 0.01% CREAM, but none are currently priced below it.
Who manufactures ESTRADIOL 0.01% CREAM?
ESTRADIOL 0.01% CREAM (NDC 66993000210) is labeled by Prasco Laboratories, and CMS classifies it as a generic product.
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