Product Information
DIVIGEL 1.25 MG GEL PACKET is a brand product labeled by Vertical Pharmaceuticals, LLC, priced at $4.2906 per GM under NDC 68025008630. Its NADAC has been published 192 times since Jun 22, 2022.
FDA first approved this application on Jun 4, 2007. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
1.25 mg/1.25g
Manufacturer
Vertical Pharmaceuticals, LLCNDC
68025008630
Classification
Brand
Dosage Form
GEL
Route
TOPICAL
Effective Date
8/19/2026
Active Ingredients
ESTRADIOLApproval Type
New Drug (NDA)
FDA Application
NDA022038FDA Approved
6/4/2007
TE Code
AB
On Market Since
12/17/2019
Pharmacological Classes
Price Statistics
The NADAC for DIVIGEL 1.25 MG GEL PACKET has been published 192 times since Jun 22, 2022, and over the history we have for it it has risen 3.6%. The table below summarizes its recorded NADAC range and movement.
| Current price | $4.2906 per GM |
|---|---|
| All-time high | $4.3230 (Feb 12, 2025) |
| All-time low | $4.1422 (Jun 22, 2022) |
| 52-week high | $4.3227 |
| 52-week low | $4.2790 |
| Median price | $4.3098 |
| Average price | $4.2944 |
| Largest weekly change | +4.1% (Sep 14, 2022) |
| Weeks tracked | 192 |
| Tracking since | Jun 22, 2022 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 81% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of DIVIGEL 1.25 MG GEL PACKET?
The current National Average Drug Acquisition Cost (NADAC) for DIVIGEL 1.25 MG GEL PACKET, manufactured by Vertical Pharmaceuticals, LLC, is $4.2906 per GM (NDC 68025008630), effective Aug 19, 2026.
How has the price of DIVIGEL 1.25 MG GEL PACKET changed over time?
Over the history we have for it, the NADAC for DIVIGEL 1.25 MG GEL PACKET has risen 3.6%. It has been tracked across 192 weekly CMS publications since Jun 22, 2022.
What are the highest and lowest recorded NADAC prices for DIVIGEL 1.25 MG GEL PACKET?
Since Jun 22, 2022, the NADAC for DIVIGEL 1.25 MG GEL PACKET has ranged from a low of $4.1422 (Jun 22, 2022) to a high of $4.3230 (Feb 12, 2025), with a median of $4.3098 per GM.
Are there cheaper alternatives to DIVIGEL 1.25 MG GEL PACKET?
Yes. 1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, ESTRADIOL 0.1% (1.25 MG) GEL PK, is $0.8042 per GM — about 81% below DIVIGEL 1.25 MG GEL PACKET.
Who manufactures DIVIGEL 1.25 MG GEL PACKET?
DIVIGEL 1.25 MG GEL PACKET (NDC 68025008630) is labeled by Vertical Pharmaceuticals, LLC, and CMS classifies it as a brand product.