Product Information
ESTRADIOL 0.1% (1.25 MG) GEL PK is a generic product labeled by Padagis Israel Pharmaceuticals Ltd, priced at $0.7335 per GM under NDC 45802057330. Its NADAC has been published 137 times since Feb 21, 2024.
FDA first approved this application on Nov 14, 2023. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
1.25 mg/1.25g
Manufacturer
Padagis Israel Pharmaceuticals LtdNDC
45802057330
Classification
Generic
Dosage Form
GEL
Route
TOPICAL
Effective Date
9/23/2026
Active Ingredients
ESTRADIOLApproval Type
Generic (ANDA)
FDA Application
ANDA216524FDA Approved
11/14/2023
TE Code
AB
On Market Since
12/7/2023
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.1% (1.25 MG) GEL PK has been published 137 times since Feb 21, 2024, and over the history we have for it it has declined 70.7%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.7335 per GM |
|---|---|
| All-time high | $2.8779 (Jun 12, 2024) |
| All-time low | $0.7335 (Sep 23, 2026) |
| 52-week high | $1.6751 |
| 52-week low | $0.7335 |
| Median price | $1.5635 |
| Average price | $1.5893 |
| Largest weekly change | -30.5% (Jun 19, 2024) |
| Weeks tracked | 137 |
| Tracking since | Feb 21, 2024 |
Generic Alternatives
The matcher finds 1 manufacturer offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
Use these direct paths to move from a single NDC into the surrounding market, manufacturer, class, and trend context.
Manufacturer
Padagis Israel Pharmaceuticals Ltd manufacturer profile
See the full portfolio, pricing trend, and other products from this labeler.
Drug market
estradiol market comparison
Compare this molecule across participating manufacturers and inspect the broader market price spread.
Therapeutic class
Estrogen class view
See how this drug behaves alongside other products in the same FDA pharmacologic class.
Trend hub
Latest market trends
Zoom back out to the weekly mover view and compare this NDC with the rest of the current NADAC release.
Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.1% (1.25 MG) GEL PK?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.1% (1.25 MG) GEL PK, manufactured by Padagis Israel Pharmaceuticals Ltd, is $0.7335 per GM (NDC 45802057330), effective Sep 30, 2026.
How has the price of ESTRADIOL 0.1% (1.25 MG) GEL PK changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.1% (1.25 MG) GEL PK has declined 70.7%. It has been tracked across 137 weekly CMS publications since Feb 21, 2024.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.1% (1.25 MG) GEL PK?
Since Feb 21, 2024, the NADAC for ESTRADIOL 0.1% (1.25 MG) GEL PK has ranged from a low of $0.7335 (Sep 23, 2026) to a high of $2.8779 (Jun 12, 2024), with a median of $1.5635 per GM.
Are there cheaper alternatives to ESTRADIOL 0.1% (1.25 MG) GEL PK?
1 manufacturer publishes a NADAC-priced product with the same active ingredient and strength as ESTRADIOL 0.1% (1.25 MG) GEL PK in a comparable dosage form, but none are currently priced below it.
Who manufactures ESTRADIOL 0.1% (1.25 MG) GEL PK?
ESTRADIOL 0.1% (1.25 MG) GEL PK (NDC 45802057330) is labeled by Padagis Israel Pharmaceuticals Ltd, and CMS classifies it as a generic product.