Product Information
ESTRADIOL 10 MCG VAGINAL INSRT is a generic product labeled by NorthStar Rx LLC, priced at $5.6451 per EA under NDC 72603087418. Its NADAC has been published 38 times since Dec 3, 2025.
FDA first approved this application on Aug 2, 2024. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
10 ug/1
Manufacturer
NorthStar Rx LLCNDC
72603087418
Classification
Generic
Dosage Form
TABLET, FILM COATED
Route
VAGINAL
Effective Date
8/19/2026
Active Ingredients
ESTRADIOL HEMIHYDRATEApproval Type
Generic (ANDA)
FDA Application
ANDA216550FDA Approved
8/2/2024
TE Code
AB
On Market Since
9/1/2025
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 10 MCG VAGINAL INSRT has been published 38 times since Dec 3, 2025, and over the history we have for it it has declined 19.5%. The table below summarizes its recorded NADAC range and movement.
| Current price | $5.6451 per EA |
|---|---|
| All-time high | $7.0095 (Dec 10, 2025) |
| All-time low | $5.6451 (Aug 19, 2026) |
| 52-week high | $7.0095 |
| 52-week low | $5.6451 |
| Median price | $6.7423 |
| Average price | $6.4936 |
| Largest weekly change | -4.7% (Apr 22, 2026) |
| Weeks tracked | 38 |
| Tracking since | Dec 3, 2025 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of ESTRADIOL 10 MCG VAGINAL INSRT?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 10 MCG VAGINAL INSRT, manufactured by NorthStar Rx LLC, is $5.6451 per EA (NDC 72603087418), effective Aug 19, 2026.
How has the price of ESTRADIOL 10 MCG VAGINAL INSRT changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 10 MCG VAGINAL INSRT has declined 19.5%. It has been tracked across 38 weekly CMS publications since Dec 3, 2025.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 10 MCG VAGINAL INSRT?
Since Dec 3, 2025, the NADAC for ESTRADIOL 10 MCG VAGINAL INSRT has ranged from a low of $5.6451 (Aug 19, 2026) to a high of $7.0095 (Dec 10, 2025), with a median of $6.7423 per EA.
Are there cheaper alternatives to ESTRADIOL 10 MCG VAGINAL INSRT?
3 manufacturers publish a NADAC-priced product with the same active ingredient and strength as ESTRADIOL 10 MCG VAGINAL INSRT in a comparable dosage form, but none are currently priced below it.
Who manufactures ESTRADIOL 10 MCG VAGINAL INSRT?
ESTRADIOL 10 MCG VAGINAL INSRT (NDC 72603087418) is labeled by NorthStar Rx LLC, and CMS classifies it as a generic product.