Methylprednisolone
28 NDCs across 9 manufacturers|25 Generic,3 Brand
Methylprednisolone is used to treat adrenal insufficiency, asthma, berylliosis, brain neoplasms, ulcerative colitis and dermatitis herpetiformis, per the National Library of Medicine's MED-RT classification.
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The brand product was first FDA-approved before 1982, and the first generic was approved Jan 1, 1982. FDA's Orange Book lists 16 AB-rated (therapeutically equivalent) products for this ingredient. In 2024, Medicare Part D spent $42 million on Methylprednisolone across 5.9 million claims for 4.5 million beneficiaries.
Methylprednisolone is available as 28 NDCs from 9 manufacturers (25 generic, 3 brand), with NADAC prices from $0.12 to $2.75 per EA — the most expensive product costs about 24× the cheapest. Every pack size and labeler in this drug market is compared side-by-side below.
Active FDA drug shortage
23 Methylprednisolone presentations are currently listed in FDA's drug shortage database (first posted Dec 15, 2021). Shortages can move NADAC prices in the following weeks.
Total NDCs
28
25G / 3B
Manufacturers
9
competing in market
Price Spread
$0.12 – $2.75
per EA
7d Activity
avg +1.2% WoW · of 28 NDCs
Market Price Trend
Monthly average NADAC per unit, split by generic and brand.
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Top supplier
Mylan Pharmaceuticals Inc. manufacturer profile
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Lead class
Corticosteroid class view
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Trend hub
Latest market trends
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Guide
How to interpret NADAC
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Manufacturer Breakdown
9 manufacturers producing METHYLPREDNISOLONE
Frequently Asked Questions
What is Methylprednisolone used to treat?
Methylprednisolone is used to treat adrenal insufficiency, asthma, berylliosis, brain neoplasms, ulcerative colitis and dermatitis herpetiformis, per the National Library of Medicine's MED-RT classification.
When did Methylprednisolone become available as a generic?
FDA approved the first generic Methylprednisolone (ANDA) on Jan 1, 1982. The Orange Book currently lists 16 AB-rated products for this ingredient, meaning FDA considers them therapeutically equivalent to the brand.
How much does Medicare spend on Methylprednisolone?
In 2024, Medicare Part D spent $42 million on Methylprednisolone across 5.9 million claims for 4.5 million beneficiaries.
Is Methylprednisolone in shortage?
Yes — FDA's drug shortage database currently lists 23 Methylprednisolone presentations with status "Current", first posted Dec 15, 2021.
How many Methylprednisolone products are on the market?
The Methylprednisolone drug market contains 28 NDCs from 9 manufacturers — 25 generic and 3 brand products.
What is the price range for Methylprednisolone?
NADAC reference prices for Methylprednisolone range from $0.1155 to $2.7549 per EA — the most expensive product costs about 24× the cheapest.
Is generic Methylprednisolone cheaper than brand?
The average generic NADAC for Methylprednisolone is $0.7229 per EA, versus $0.7022 for brand-labeled products — brand is currently about 3% cheaper on average.
Which manufacturers make Methylprednisolone?
9 manufacturers list Methylprednisolone in NADAC. Ranked by number of NDCs, the largest are Mylan Pharmaceuticals Inc. (5), Zydus Pharmaceuticals (USA) Inc. (5), BluePoint Laboratories (5), Chartwell RX LLC (4), Pharmacia & Upjohn Company LLC (3).
How has the price of Methylprednisolone changed recently?
Over the past 7 days, 12 Methylprednisolone NDCs rose and 9 fell, with a market-wide average change of +1.2%.