Product Information
PREMARIN VAGINAL CREAM-APPL is a brand product labeled by Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc., priced at $15.0838 per GM under NDC 00046087221. Its NADAC has been published 665 times since Nov 28, 2013.
FDA first approved this application before 1982.
Strength
.625 mg/g
NDC
00046087221
Classification
Brand
Dosage Form
CREAM
Route
VAGINAL
Effective Date
8/19/2026
Active Ingredients
ESTROGENS, CONJUGATEDApproval Type
New Drug (NDA)
FDA Application
NDA020216FDA Approved
Before 1982
On Market Since
11/1/1978
Pharmacological Classes
Price Statistics
The NADAC for PREMARIN VAGINAL CREAM-APPL has been published 665 times since Nov 28, 2013, and over the history we have for it it has risen 144.3%. The table below summarizes its recorded NADAC range and movement.
| Current price | $15.0838 per GM |
|---|---|
| All-time high | $15.0991 (May 13, 2026) |
| All-time low | $6.1733 (Nov 28, 2013) |
| 52-week high | $15.0991 |
| 52-week low | $14.6983 |
| Median price | $12.5386 |
| Average price | $11.8956 |
| Largest weekly change | +9.4% (Jan 6, 2016) |
| Weeks tracked | 665 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
No other NADAC-published product shares this drug's active ingredient and strength in a comparable dosage form. Compare the broader picture on the conjugated estrogens market page.
Lowest-Cost Alternatives
No alternatives available
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of PREMARIN VAGINAL CREAM-APPL?
The current National Average Drug Acquisition Cost (NADAC) for PREMARIN VAGINAL CREAM-APPL, manufactured by Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc., is $15.0838 per GM (NDC 00046087221), effective Aug 19, 2026.
How has the price of PREMARIN VAGINAL CREAM-APPL changed over time?
Over the history we have for it, the NADAC for PREMARIN VAGINAL CREAM-APPL has risen 144.3%. It has been tracked across 665 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for PREMARIN VAGINAL CREAM-APPL?
Since Nov 28, 2013, the NADAC for PREMARIN VAGINAL CREAM-APPL has ranged from a low of $6.1733 (Nov 28, 2013) to a high of $15.0991 (May 13, 2026), with a median of $12.5386 per GM.
Are there cheaper alternatives to PREMARIN VAGINAL CREAM-APPL?
No other NADAC-published product currently shares the active ingredient and strength of PREMARIN VAGINAL CREAM-APPL in a comparable dosage form, so no direct lower-cost alternative is listed.
Who manufactures PREMARIN VAGINAL CREAM-APPL?
PREMARIN VAGINAL CREAM-APPL (NDC 00046087221) is labeled by Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc., and CMS classifies it as a brand product.