Product Information
ESTRADIOL 0.0375 MG PATCH(1/WK) is a generic product labeled by Mylan Pharmaceuticals Inc., priced at $11.9304 per EA under NDC 00378336099. Its NADAC has been published 671 times since Nov 28, 2013.
FDA first approved this application on Feb 24, 2000. Its Orange Book therapeutic-equivalence code is AB2 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.0375 mg/d
Manufacturer
Mylan Pharmaceuticals Inc.NDC
00378336099
Classification
Generic
Dosage Form
PATCH
Route
TRANSDERMAL
Effective Date
9/23/2026
Active Ingredients
ESTRADIOLApproval Type
Generic (ANDA)
FDA Application
ANDA075182FDA Approved
2/24/2000
TE Code
AB2
On Market Since
8/9/2006
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.0375 MG PATCH(1/WK) has been published 671 times since Nov 28, 2013, and over the history we have for it it has declined 6.8%. The table below summarizes its recorded NADAC range and movement.
| Current price | $11.9304 per EA |
|---|---|
| All-time high | $16.8536 (Aug 12, 2015) |
| All-time low | $9.4369 (Oct 18, 2023) |
| 52-week high | $12.2291 |
| 52-week low | $10.8148 |
| Median price | $14.0081 |
| Average price | $13.7763 |
| Largest weekly change | +40.2% (Nov 22, 2023) |
| Weeks tracked | 671 |
| Tracking since | Nov 28, 2013 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 31% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Mylan Pharmaceuticals Inc. manufacturer profile
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Drug market
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Therapeutic class
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.0375 MG PATCH(1/WK)?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.0375 MG PATCH(1/WK), manufactured by Mylan Pharmaceuticals Inc., is $11.9304 per EA (NDC 00378336099), effective Sep 30, 2026.
How has the price of ESTRADIOL 0.0375 MG PATCH(1/WK) changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.0375 MG PATCH(1/WK) has declined 6.8%. It has been tracked across 671 weekly CMS publications since Nov 28, 2013.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.0375 MG PATCH(1/WK)?
Since Nov 28, 2013, the NADAC for ESTRADIOL 0.0375 MG PATCH(1/WK) has ranged from a low of $9.4369 (Oct 18, 2023) to a high of $16.8536 (Aug 12, 2015), with a median of $14.0081 per EA.
Are there cheaper alternatives to ESTRADIOL 0.0375 MG PATCH(1/WK)?
Yes. 2 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, ESTRADIOL 0.0375 MG PATCH(2/WK), is $8.2623 per EA — about 31% below ESTRADIOL 0.0375 MG PATCH(1/WK).
Who manufactures ESTRADIOL 0.0375 MG PATCH(1/WK)?
ESTRADIOL 0.0375 MG PATCH(1/WK) (NDC 00378336099) is labeled by Mylan Pharmaceuticals Inc., and CMS classifies it as a generic product.