Product Information
ESTRADIOL 0.0375 MG PATCH(2/WK) is a generic product labeled by Mylan Pharmaceuticals Inc., priced at $8.2278 per EA under NDC 00378462026. Its NADAC has been published 399 times since Jan 2, 2019.
FDA first approved this application on Aug 15, 2018. Its Orange Book therapeutic-equivalence code is AB3 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.0375 mg/d
Manufacturer
Mylan Pharmaceuticals Inc.NDC
00378462026
Classification
Generic
Dosage Form
PATCH
Route
TRANSDERMAL
Effective Date
8/19/2026
Active Ingredients
ESTRADIOLApproval Type
Generic (ANDA)
FDA Application
ANDA206685FDA Approved
8/15/2018
TE Code
AB3
On Market Since
11/1/2018
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.0375 MG PATCH(2/WK) has been published 399 times since Jan 2, 2019, and over the history we have for it it has risen 2.4%. The table below summarizes its recorded NADAC range and movement.
| Current price | $8.2278 per EA |
|---|---|
| All-time high | $10.3341 (Apr 13, 2022) |
| All-time low | $5.3236 (Nov 20, 2024) |
| 52-week high | $8.2278 |
| 52-week low | $6.6398 |
| Median price | $7.1355 |
| Average price | $7.3606 |
| Largest weekly change | +29.5% (Mar 23, 2022) |
| Weeks tracked | 399 |
| Tracking since | Jan 2, 2019 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.0375 MG PATCH(2/WK)?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.0375 MG PATCH(2/WK), manufactured by Mylan Pharmaceuticals Inc., is $8.2278 per EA (NDC 00378462026), effective Aug 19, 2026.
How has the price of ESTRADIOL 0.0375 MG PATCH(2/WK) changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.0375 MG PATCH(2/WK) has risen 2.4%. It has been tracked across 399 weekly CMS publications since Jan 2, 2019.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.0375 MG PATCH(2/WK)?
Since Jan 2, 2019, the NADAC for ESTRADIOL 0.0375 MG PATCH(2/WK) has ranged from a low of $5.3236 (Nov 20, 2024) to a high of $10.3341 (Apr 13, 2022), with a median of $7.1355 per EA.
Are there cheaper alternatives to ESTRADIOL 0.0375 MG PATCH(2/WK)?
2 manufacturers publish a NADAC-priced product with the same active ingredient and strength as ESTRADIOL 0.0375 MG PATCH(2/WK) in a comparable dosage form, but none are currently priced below it.
Who manufactures ESTRADIOL 0.0375 MG PATCH(2/WK)?
ESTRADIOL 0.0375 MG PATCH(2/WK) (NDC 00378462026) is labeled by Mylan Pharmaceuticals Inc., and CMS classifies it as a generic product.