Product Information
ESTRADIOL 0.0375 MG PATCH(2/WK) is a generic product labeled by Sandoz Inc., priced at $8.2623 per EA under NDC 00781713883. Its NADAC has been published 539 times since Jun 8, 2016.
FDA first approved this application on Jan 8, 1999. Its Orange Book therapeutic-equivalence code is AB1 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.0375 mg/d
Manufacturer
Sandoz Inc.NDC
00781713883
Classification
Generic
Dosage Form
PATCH, EXTENDED RELEASE
Route
TRANSDERMAL
Effective Date
9/23/2026
Active Ingredients
ESTRADIOLApproval Type
Authorized Generic (NDA)
FDA Application
NDA020538FDA Approved
1/8/1999
TE Code
AB1
On Market Since
12/22/2014
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.0375 MG PATCH(2/WK) has been published 539 times since Jun 8, 2016, and over the history we have for it it has declined 2.5%. The table below summarizes its recorded NADAC range and movement.
| Current price | $8.2623 per EA |
|---|---|
| All-time high | $10.3341 (Apr 13, 2022) |
| All-time low | $5.3236 (Nov 20, 2024) |
| 52-week high | $8.2623 |
| 52-week low | $6.6398 |
| Median price | $7.5887 |
| Average price | $7.6637 |
| Largest weekly change | +29.5% (Mar 23, 2022) |
| Weeks tracked | 539 |
| Tracking since | Jun 8, 2016 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Sandoz Inc. manufacturer profile
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Therapeutic class
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Trend hub
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Guide
Understanding NADAC pricing
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Frequently asked questions
What is the NADAC price of ESTRADIOL 0.0375 MG PATCH(2/WK)?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.0375 MG PATCH(2/WK), manufactured by Sandoz Inc., is $8.2623 per EA (NDC 00781713883), effective Sep 30, 2026.
How has the price of ESTRADIOL 0.0375 MG PATCH(2/WK) changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.0375 MG PATCH(2/WK) has declined 2.5%. It has been tracked across 539 weekly CMS publications since Jun 8, 2016.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.0375 MG PATCH(2/WK)?
Since Jun 8, 2016, the NADAC for ESTRADIOL 0.0375 MG PATCH(2/WK) has ranged from a low of $5.3236 (Nov 20, 2024) to a high of $10.3341 (Apr 13, 2022), with a median of $7.5887 per EA.
Are there cheaper alternatives to ESTRADIOL 0.0375 MG PATCH(2/WK)?
2 manufacturers publish a NADAC-priced product with the same active ingredient and strength as ESTRADIOL 0.0375 MG PATCH(2/WK) in a comparable dosage form, but none are currently priced below it.
Who manufactures ESTRADIOL 0.0375 MG PATCH(2/WK)?
ESTRADIOL 0.0375 MG PATCH(2/WK) (NDC 00781713883) is labeled by Sandoz Inc., and CMS classifies it as a generic product.