Product Information
TRETINOIN 0.1% CREAM is a generic product labeled by Padagis US LLC, priced at $0.9196 per GM under NDC 00574220120. Its NADAC has been published 487 times since Jun 7, 2017.
FDA first approved this application on Dec 24, 1998. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
1 mg/g
Manufacturer
Padagis US LLCNDC
00574220120
Classification
Generic
Dosage Form
CREAM
Route
TOPICAL
Effective Date
9/23/2026
Active Ingredients
TRETINOINApproval Type
Generic (ANDA)
FDA Application
ANDA075213FDA Approved
12/24/1998
TE Code
AB
On Market Since
3/30/2017
Pharmacological Classes
Price Statistics
The NADAC for TRETINOIN 0.1% CREAM has been published 487 times since Jun 7, 2017, and over the history we have for it it has declined 80.4%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.9196 per GM |
|---|---|
| All-time high | $5.3026 (Feb 14, 2018) |
| All-time low | $0.9196 (Sep 23, 2026) |
| 52-week high | $1.2697 |
| 52-week low | $0.9196 |
| Median price | $2.9058 |
| Average price | $3.1216 |
| Largest weekly change | -36.0% (Nov 20, 2024) |
| Weeks tracked | 487 |
| Tracking since | Jun 7, 2017 |
Generic Alternatives
The matcher finds 2 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). Switching to the cheapest would cut per-unit acquisition cost by roughly 16% at current NADAC. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Padagis US LLC manufacturer profile
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Drug market
tretinoin market comparison
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Therapeutic class
Retinoid class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of TRETINOIN 0.1% CREAM?
The current National Average Drug Acquisition Cost (NADAC) for TRETINOIN 0.1% CREAM, manufactured by Padagis US LLC, is $0.9196 per GM (NDC 00574220120), effective Sep 30, 2026.
How has the price of TRETINOIN 0.1% CREAM changed over time?
Over the history we have for it, the NADAC for TRETINOIN 0.1% CREAM has declined 80.4%. It has been tracked across 487 weekly CMS publications since Jun 7, 2017.
What are the highest and lowest recorded NADAC prices for TRETINOIN 0.1% CREAM?
Since Jun 7, 2017, the NADAC for TRETINOIN 0.1% CREAM has ranged from a low of $0.9196 (Sep 23, 2026) to a high of $5.3026 (Feb 14, 2018), with a median of $2.9058 per GM.
Are there cheaper alternatives to TRETINOIN 0.1% CREAM?
Yes. 2 manufacturers publish a NADAC-priced product with the same active ingredient and strength in a comparable dosage form. The lowest-priced option, TRETINOIN 0.1% CREAM, is $0.7701 per GM — about 16% below TRETINOIN 0.1% CREAM.
Who manufactures TRETINOIN 0.1% CREAM?
TRETINOIN 0.1% CREAM (NDC 00574220120) is labeled by Padagis US LLC, and CMS classifies it as a generic product.