Tretinoin

83 NDCs across 15 manufacturers|59 Generic,24 Brand

Tretinoin is used to treat acne vulgaris, facial dermatoses, hyperpigmentation and leukemia, promyelocytic, acute, per the National Library of Medicine's MED-RT classification.

▸ More about this market

The brand product was first FDA-approved before 1982, and the first generic was approved Jun 19, 1998. FDA's Orange Book lists 34 AB-rated (therapeutically equivalent) products for this ingredient. In 2024, Medicare Part D spent $22 million on Tretinoin across 268,000 claims for 131,000 beneficiaries.

Tretinoin is available as 83 NDCs from 15 manufacturers (59 generic, 24 brand), with NADAC prices from $0.47 to $17.76 per GM — the most expensive product costs about 38× the cheapest. Every pack size and labeler in this drug market is compared side-by-side below.

Total NDCs

59G / 24B

Manufacturers

competing in market

Price Spread

$0.47 – $17.76

per GM, 79 of 83 NDCs

7d Activity

25↑26↓32 flat

avg -0.2% WoW · of 83 NDCs

Market Price Trend

Monthly average NADAC per unit, split by generic and brand.

Manufacturer Breakdown

15 manufacturers producing TRETINOIN

Mylan Pharmaceuticals Inc.

Oceanside Pharmaceuticals

8 NDCs

$8.4266

avg/unit

Sun Pharmaceutical Industries Inc.

Encube Ethicals, Inc.

5 NDCs

$4.7077

avg/unit

Alembic Pharmaceuticals Inc.

4 NDCs

$0.6855

avg/unit

Viona Pharmaceuticals Inc.

Major Pharmaceuticals

1 NDC

$8.5310

avg/unit

Glenmark Pharmaceuticals Inc., USA

1 NDC

$8.5310

avg/unit

American Health Packaging

Drug Portfolio

83 NDCs total, 83 shown

Drug ↕	NDC	Manufacturer ↕	Price	Market Outlier	Class	7d Change ↕	Therapeutic Class
RETIN-A MICRO 0.1% GEL	00187514020	Bausch Health US LLC	$17.7570 per GM	—	Brand	—	Retinoid
RETIN-A MICRO PUMP 0.08% GEL	00187514850	Bausch Health US LLC	$17.4513 per GM	—	Brand	—	Retinoid
RETIN-A MICRO PUMP 0.06% GEL	00187514650	Bausch Health US LLC	$17.3944 per GM	—	Brand	—	Retinoid
RETIN-A MICRO PUMP 0.1% GEL	00187514050	Bausch Health US LLC	$16.4877 per GM	—	Brand	—	Retinoid
RETIN-A MICRO 0.04% GEL	00187514420	Bausch Health US LLC	$16.2484 per GM	—	Brand	—	Retinoid
RETIN-A MICRO PUMP 0.04% GEL	00187514450	Bausch Health US LLC	$14.8203 per GM	—	Brand	—	Retinoid
RETIN-A MICRO 0.04% GEL	00187514445	Bausch Health US LLC	$14.3619 per GM	—	Brand	—	Retinoid
RETIN-A MICRO 0.1% GEL	00187514045	Bausch Health US LLC	$13.9968 per GM	—	Brand	—	Retinoid
TRETINOIN GEL MICRO 0.08% PUMP	68682051595	Oceanside Pharmaceuticals	$11.9864 per GM	—	Generic	—	Retinoid
ATRALIN 0.05% GEL	13548007045	Bausch Health US LLC	$11.9379 per GM	—	Brand	—	Retinoid
TRETINOIN GEL MICRO 0.08% PUMP	68308077750	Mayne Pharma	$11.6297 per GM	—	Generic	+9.78%	Retinoid
TRETINOIN GEL MICRO 0.08% PUMP	21922004340	Encube Ethicals, Inc.	$11.6297 per GM	—	Generic	+9.78%	Retinoid
TRETINOIN GEL MICRO 0.04% TUBE	68682051492	Oceanside Pharmaceuticals	$10.3452 per GM	—	Generic	—	Retinoid
TRETINOIN GEL MICRO 0.04% PUMP	68682051495	Oceanside Pharmaceuticals	$9.4854 per GM	—	Generic	—	Retinoid
TRETINOIN GEL MICRO 0.1% TUBE	68682051382	Oceanside Pharmaceuticals	$9.4206 per GM	—	Generic	—	Retinoid
TRETINOIN 10 MG CAPSULE	00904686704	Major Pharmaceuticals	$8.5310 per EA	—	Generic	-2.62%	Retinoid
TRETINOIN 10 MG CAPSULE	68462079201	Glenmark Pharmaceuticals Inc., USA	$8.5310 per EA	—	Generic	-2.62%	Retinoid
TRETINOIN 10 MG CAPSULE	68084007521	American Health Packaging	$8.5310 per EA	—	Generic	-2.62%	Retinoid
TRETINOIN 10 MG CAPSULE	10370026801	Endo USA Inc.	$8.5310 per EA	—	Generic	-2.62%	Retinoid
TRETINOIN GEL MICRO 0.1% PUMP	68682051385	Oceanside Pharmaceuticals	$7.6257 per GM	—	Generic	—	Retinoid
TRETINOIN GEL MICRO 0.1% TUBE	68682051384	Oceanside Pharmaceuticals	$7.4226 per GM	—	Generic	—	Retinoid
TRETINOIN GEL MICRO 0.04% TUBE	68682051494	Oceanside Pharmaceuticals	$6.9393 per GM	—	Generic	—	Retinoid
RENOVA 0.02% CREAM	00187515040	Bausch Health US LLC	$6.2881 per GM	—	Brand	—	Retinoid
RENOVA 0.02% CREAM	00187515060	Bausch Health US LLC	$4.6748 per GM	—	Brand	—	Retinoid
TRETINOIN 0.05% GEL	68682080045	Oceanside Pharmaceuticals	$4.1874 per GM	—	Generic	—	Retinoid
TRETINOIN 0.05% GEL	00378809045	Mylan Pharmaceuticals Inc.	$4.0004 per GM	—	Generic	-3.29%	Retinoid
TRETINOIN 0.025% GEL	21922005704	Encube Ethicals, Inc.	$3.7790 per GM	—	Generic	+2.93%	Retinoid
TRETINOIN 0.025% GEL	00378808615	Mylan Pharmaceuticals Inc.	$3.7790 per GM	—	Generic	+2.93%	Retinoid
TRETINOIN 0.025% GEL	00574232515	Padagis US LLC	$3.7790 per GM	—	Generic	+2.93%	Retinoid
TRETINOIN 0.01% GEL	00574230115	Padagis US LLC	$3.1147 per GM	—	Generic	-5.90%	Retinoid
TRETINOIN 0.01% GEL	00378808515	Mylan Pharmaceuticals Inc.	$3.1147 per GM	—	Generic	-5.90%	Retinoid
TRETINOIN 0.01% GEL	21922005604	Encube Ethicals, Inc.	$3.1147 per GM	—	Generic	-5.90%	Retinoid
TRETINOIN 0.025% GEL	00574232545	Padagis US LLC	$2.7073 per GM	—	Generic	+0.30%	Retinoid
TRETINOIN 0.025% GEL	21922005706	Encube Ethicals, Inc.	$2.7073 per GM	—	Generic	+0.30%	Retinoid
TRETINOIN 0.025% GEL	00378808645	Mylan Pharmaceuticals Inc.	$2.7073 per GM	—	Generic	+0.30%	Retinoid
ALTRENO 0.05% LOTION	00187000545	Bausch Health US LLC	$2.4494 per GM	—	Brand	—	Retinoid
ALTRENO 0.05% LOTION	00187000520	Bausch Health US LLC	$2.3934 per GM	—	Brand	—	Retinoid
RENOVA 0.02% CREAM	00187515020	Bausch Health US LLC	$2.3556 per GM	—	Brand	—	Retinoid
TRETINOIN 0.01% GEL	00378808545	Mylan Pharmaceuticals Inc.	$2.3076 per GM	—	Generic	+2.64%	Retinoid
TRETINOIN 0.01% GEL	00574230145	Padagis US LLC	$2.3076 per GM	—	Generic	+2.64%	Retinoid
TRETINOIN 0.01% GEL	21922005606	Encube Ethicals, Inc.	$2.3076 per GM	—	Generic	+2.64%	Retinoid
TRETINOIN 0.05% CREAM	51672139400	Sun Pharmaceutical Industries Inc.	$1.5688 per GM	—	Generic	+1.23%	Retinoid
TRETINOIN 0.05% CREAM	16714024901	NorthStar Rx LLC	$1.5688 per GM	—	Generic	+1.23%	Retinoid
TRETINOIN 0.05% CREAM	00378808320	Mylan Pharmaceuticals Inc.	$1.5688 per GM	—	Generic	+1.23%	Retinoid
TRETINOIN 0.05% CREAM	00574220520	Padagis US LLC	$1.5688 per GM	—	Generic	+1.23%	Retinoid
RETIN-A 0.01% GEL	00187517215	Bausch Health US LLC	$0.9600 per GM	—	Brand	—	Retinoid
RETIN-A 0.1% CREAM	00187516445	Bausch Health US LLC	$0.9594 per GM	—	Brand	—	Retinoid
RETIN-A 0.1% CREAM	00187516420	Bausch Health US LLC	$0.9594 per GM	—	Brand	—	Retinoid
RETIN-A 0.025% GEL	00187517015	Bausch Health US LLC	$0.9592 per GM	—	Brand	—	Retinoid
RETIN-A 0.025% GEL	00187517045	Bausch Health US LLC	$0.9582 per GM	—	Brand	—	Retinoid
TRETINOIN 0.1% CREAM	00574220120	Padagis US LLC	$0.9575 per GM	—	Generic	+1.63%	Retinoid
TRETINOIN 0.1% CREAM	62332080720	Alembic Pharmaceuticals Inc.	$0.9575 per GM	—	Generic	+1.63%	Retinoid
TRETINOIN 0.1% CREAM	51672139500	Sun Pharmaceutical Industries Inc.	$0.9575 per GM	—	Generic	+1.63%	Retinoid
TRETINOIN 0.1% CREAM	00378808420	Mylan Pharmaceuticals Inc.	$0.9575 per GM	—	Generic	+1.63%	Retinoid
TRETINOIN 0.1% CREAM	16714025001	NorthStar Rx LLC	$0.9575 per GM	—	Generic	+1.63%	Retinoid
TRETINOIN 0.1% CREAM	72578015309	Viona Pharmaceuticals Inc.	$0.9575 per GM	—	Generic	+1.63%	Retinoid
RETIN-A 0.01% GEL	00187517245	Bausch Health US LLC	$0.9570 per GM	—	Brand	—	Retinoid
TRETINOIN 0.05% CREAM	51672139409	Sun Pharmaceutical Industries Inc.	$0.9284 per GM	—	Generic	+2.43%	Retinoid
TRETINOIN 0.05% CREAM	16714024902	NorthStar Rx LLC	$0.9284 per GM	—	Generic	+2.43%	Retinoid
TRETINOIN 0.05% CREAM	00574220545	Padagis US LLC	$0.9284 per GM	—	Generic	+2.43%	Retinoid
TRETINOIN 0.05% CREAM	00378808345	Mylan Pharmaceuticals Inc.	$0.9284 per GM	—	Generic	+2.43%	Retinoid
RETIN-A 0.05% CREAM	00187516220	Bausch Health US LLC	$0.7914 per GM	—	Brand	—	Retinoid
RETIN-A 0.025% CREAM	00187516020	Bausch Health US LLC	$0.7907 per GM	—	Brand	—	Retinoid
RETIN-A 0.025% CREAM	00187516045	Bausch Health US LLC	$0.7904 per GM	—	Brand	—	Retinoid
RETIN-A 0.05% CREAM	00187516245	Bausch Health US LLC	$0.7904 per GM	—	Brand	—	Retinoid
TRETINOIN 0.1% CREAM	72578015308	Viona Pharmaceuticals Inc.	$0.7625 per GM	—	Generic	-3.62%	Retinoid
TRETINOIN 0.1% CREAM	16714025002	NorthStar Rx LLC	$0.7625 per GM	—	Generic	-3.62%	Retinoid
TRETINOIN 0.1% CREAM	00574220145	Padagis US LLC	$0.7625 per GM	—	Generic	-3.62%	Retinoid
TRETINOIN 0.1% CREAM	00378808445	Mylan Pharmaceuticals Inc.	$0.7625 per GM	—	Generic	-3.62%	Retinoid
TRETINOIN 0.1% CREAM	62332080745	Alembic Pharmaceuticals Inc.	$0.7625 per GM	—	Generic	-3.62%	Retinoid
TRETINOIN 0.1% CREAM	51672139509	Sun Pharmaceutical Industries Inc.	$0.7625 per GM	—	Generic	-3.62%	Retinoid
TRETINOIN 0.025% CREAM	62332080920	Alembic Pharmaceuticals Inc.	$0.5535 per GM	—	Generic	-1.42%	Retinoid
TRETINOIN 0.025% CREAM	00378808220	Mylan Pharmaceuticals Inc.	$0.5535 per GM	—	Generic	-1.42%	Retinoid
TRETINOIN 0.025% CREAM	00472011720	Actavis Pharma, Inc.	$0.5535 per GM	—	Generic	-1.42%	Retinoid
TRETINOIN 0.025% CREAM	00574222520	Padagis US LLC	$0.5535 per GM	—	Generic	-1.42%	Retinoid
TRETINOIN 0.025% CREAM	51672140700	Sun Pharmaceutical Industries Inc.	$0.5535 per GM	—	Generic	-1.42%	Retinoid
TRETINOIN 0.025% CREAM	16714027001	NorthStar Rx LLC	$0.5535 per GM	—	Generic	-1.42%	Retinoid
TRETINOIN 0.025% CREAM	16714027002	NorthStar Rx LLC	$0.4684 per GM	—	Generic	-1.63%	Retinoid
TRETINOIN 0.025% CREAM	00472011745	Actavis Pharma, Inc.	$0.4684 per GM	—	Generic	-1.63%	Retinoid
TRETINOIN 0.025% CREAM	00574222545	Padagis US LLC	$0.4684 per GM	—	Generic	-1.63%	Retinoid
TRETINOIN 0.025% CREAM	00378808245	Mylan Pharmaceuticals Inc.	$0.4684 per GM	—	Generic	-1.63%	Retinoid
TRETINOIN 0.025% CREAM	62332080945	Alembic Pharmaceuticals Inc.	$0.4684 per GM	—	Generic	-1.63%	Retinoid
TRETINOIN 0.025% CREAM	51672140709	Sun Pharmaceutical Industries Inc.	$0.4684 per GM	—	Generic	-1.63%	Retinoid

Frequently Asked Questions

What is Tretinoin used to treat?

Tretinoin is used to treat acne vulgaris, facial dermatoses, hyperpigmentation and leukemia, promyelocytic, acute, per the National Library of Medicine's MED-RT classification.

When did Tretinoin become available as a generic?

FDA approved the first generic Tretinoin (ANDA) on Jun 19, 1998. The Orange Book currently lists 34 AB-rated products for this ingredient, meaning FDA considers them therapeutically equivalent to the brand.

How much does Medicare spend on Tretinoin?

In 2024, Medicare Part D spent $22 million on Tretinoin across 268,000 claims for 131,000 beneficiaries.

How many Tretinoin products are on the market?

The Tretinoin drug market contains 83 NDCs from 15 manufacturers — 59 generic and 24 brand products.

What is the price range for Tretinoin?

NADAC reference prices for Tretinoin range from $0.4684 to $17.7570 per GM — the most expensive product costs about 38× the cheapest. 4 additional products are priced per different units (e.g. liquids per ML) and aren't directly comparable.

Is generic Tretinoin cheaper than brand?

The average generic NADAC for Tretinoin is $2.8516 per GM, versus $6.9805 for brand-labeled products — brand versions average about 2.4× the generic price.

Which manufacturers make Tretinoin?

15 manufacturers list Tretinoin in NADAC. Ranked by number of NDCs, the largest are Bausch Health US LLC (24), Mylan Pharmaceuticals Inc. (11), Padagis US LLC (10), Oceanside Pharmaceuticals (8), Sun Pharmaceutical Industries Inc. (6).

How has the price of Tretinoin changed recently?

Over the past 7 days, 25 Tretinoin NDCs rose and 26 fell, with a market-wide average change of -0.2%.