Product Information
BUPROPION HCL XL 300 MG TABLET is a generic product labeled by Major Pharmaceuticals, priced at $0.1004 per EA under NDC 00904746904. Its NADAC has been published 89 times since Jan 22, 2025.
FDA first approved this application on Apr 6, 2017. Its Orange Book therapeutic-equivalence code is AB3 — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
300 mg/1
Manufacturer
Major PharmaceuticalsNDC
00904746904
Classification
Generic
Dosage Form
TABLET, EXTENDED RELEASE
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
BUPROPION HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA090693FDA Approved
4/6/2017
TE Code
AB3
On Market Since
10/7/2024
Pharmacological Classes
Price Statistics
The NADAC for BUPROPION HCL XL 300 MG TABLET has been published 89 times since Jan 22, 2025, and over the history we have for it it has declined 24.7%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.1004 per EA |
|---|---|
| All-time high | $0.1561 (Apr 16, 2025) |
| All-time low | $0.1004 (Sep 23, 2026) |
| 52-week high | $0.1461 |
| 52-week low | $0.1004 |
| Median price | $0.1334 |
| Average price | $0.1298 |
| Largest weekly change | -12.6% (Feb 18, 2026) |
| Weeks tracked | 89 |
| Tracking since | Jan 22, 2025 |
Generic Alternatives
The matcher finds 8 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
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Manufacturer
Major Pharmaceuticals manufacturer profile
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Drug market
Bupropion Hydrochloride market comparison
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Therapeutic class
Aminoketone class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of BUPROPION HCL XL 300 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for BUPROPION HCL XL 300 MG TABLET, manufactured by Major Pharmaceuticals, is $0.1004 per EA (NDC 00904746904), effective Sep 30, 2026.
How has the price of BUPROPION HCL XL 300 MG TABLET changed over time?
Over the history we have for it, the NADAC for BUPROPION HCL XL 300 MG TABLET has declined 24.7%. It has been tracked across 89 weekly CMS publications since Jan 22, 2025.
What are the highest and lowest recorded NADAC prices for BUPROPION HCL XL 300 MG TABLET?
Since Jan 22, 2025, the NADAC for BUPROPION HCL XL 300 MG TABLET has ranged from a low of $0.1004 (Sep 23, 2026) to a high of $0.1561 (Apr 16, 2025), with a median of $0.1334 per EA.
Are there cheaper alternatives to BUPROPION HCL XL 300 MG TABLET?
8 manufacturers publish a NADAC-priced product with the same active ingredient and strength as BUPROPION HCL XL 300 MG TABLET in a comparable dosage form, but none are currently priced below it.
Who manufactures BUPROPION HCL XL 300 MG TABLET?
BUPROPION HCL XL 300 MG TABLET (NDC 00904746904) is labeled by Major Pharmaceuticals, and CMS classifies it as a generic product.