Product Information
BUPROPION HCL 100 MG TABLET is a generic product labeled by Major Pharmaceuticals, priced at $0.1129 per EA under NDC 00904753060. Its NADAC has been published 76 times since Apr 23, 2025.
FDA first approved this application on Aug 19, 2016. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
100 mg/1
Manufacturer
Major PharmaceuticalsNDC
00904753060
Classification
Generic
Dosage Form
TABLET
Route
ORAL
Effective Date
9/23/2026
Active Ingredients
BUPROPION HYDROCHLORIDEApproval Type
Generic (ANDA)
FDA Application
ANDA206975FDA Approved
8/19/2016
TE Code
AB
On Market Since
1/30/2025
Pharmacological Classes
Price Statistics
The NADAC for BUPROPION HCL 100 MG TABLET has been published 76 times since Apr 23, 2025, and over the history we have for it it has declined 11.3%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.1129 per EA |
|---|---|
| All-time high | $0.1273 (May 14, 2025) |
| All-time low | $0.1129 (Sep 23, 2026) |
| 52-week high | $0.1247 |
| 52-week low | $0.1129 |
| Median price | $0.1212 |
| Average price | $0.1212 |
| Largest weekly change | -3.1% (May 20, 2026) |
| Weeks tracked | 76 |
| Tracking since | Apr 23, 2025 |
Generic Alternatives
The matcher finds 9 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
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Manufacturer
Major Pharmaceuticals manufacturer profile
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Drug market
Bupropion Hydrochloride market comparison
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Therapeutic class
Aminoketone class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of BUPROPION HCL 100 MG TABLET?
The current National Average Drug Acquisition Cost (NADAC) for BUPROPION HCL 100 MG TABLET, manufactured by Major Pharmaceuticals, is $0.1129 per EA (NDC 00904753060), effective Sep 30, 2026.
How has the price of BUPROPION HCL 100 MG TABLET changed over time?
Over the history we have for it, the NADAC for BUPROPION HCL 100 MG TABLET has declined 11.3%. It has been tracked across 76 weekly CMS publications since Apr 23, 2025.
What are the highest and lowest recorded NADAC prices for BUPROPION HCL 100 MG TABLET?
Since Apr 23, 2025, the NADAC for BUPROPION HCL 100 MG TABLET has ranged from a low of $0.1129 (Sep 23, 2026) to a high of $0.1273 (May 14, 2025), with a median of $0.1212 per EA.
Are there cheaper alternatives to BUPROPION HCL 100 MG TABLET?
9 manufacturers publish a NADAC-priced product with the same active ingredient and strength as BUPROPION HCL 100 MG TABLET in a comparable dosage form, but none are currently priced below it.
Who manufactures BUPROPION HCL 100 MG TABLET?
BUPROPION HCL 100 MG TABLET (NDC 00904753060) is labeled by Major Pharmaceuticals, and CMS classifies it as a generic product.