Product Information
ESTRADIOL 0.1% (0.25 MG) GEL PK is a generic product labeled by Trigen Laboratories, LLC, priced at $0.7570 per EA under NDC 13811009032. Its NADAC has been published 155 times since Oct 18, 2023.
FDA first approved this application on Jun 4, 2007. Its Orange Book therapeutic-equivalence code is AB — FDA rates it therapeutically equivalent to (substitutable for) its reference product.
Strength
.25 mg/.25g
Manufacturer
Trigen Laboratories, LLCNDC
13811009032
Classification
Generic
Dosage Form
GEL
Route
TOPICAL
Effective Date
9/23/2026
Active Ingredients
ESTRADIOLApproval Type
New Drug (NDA)
FDA Application
NDA022038FDA Approved
6/4/2007
TE Code
AB
On Market Since
10/10/2022
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.1% (0.25 MG) GEL PK has been published 155 times since Oct 18, 2023, and over the history we have for it it has declined 77.8%. The table below summarizes its recorded NADAC range and movement.
| Current price | $0.7570 per EA |
|---|---|
| All-time high | $3.7861 (Apr 10, 2024) |
| All-time low | $0.7570 (Sep 23, 2026) |
| 52-week high | $1.9622 |
| 52-week low | $0.7570 |
| Median price | $1.7501 |
| Average price | $2.0169 |
| Largest weekly change | +54.8% (Sep 18, 2024) |
| Weeks tracked | 155 |
| Tracking since | Oct 18, 2023 |
Generic Alternatives
The matcher finds 3 manufacturers offering a NADAC-published product with this drug's active ingredient and strength in a comparable dosage form (cheapest from each manufacturer, up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Related Drugs
Same classification
Continue researching this drug
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Manufacturer
Trigen Laboratories, LLC manufacturer profile
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Drug market
Estradiol market comparison
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Therapeutic class
Estrogen class view
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Trend hub
Latest market trends
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Guide
Understanding NADAC pricing
Use the explainer when you need context on how CMS publishes NADAC and how to interpret the number on this page.
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.1% (0.25 MG) GEL PK?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.1% (0.25 MG) GEL PK, manufactured by Trigen Laboratories, LLC, is $0.7570 per EA (NDC 13811009032), effective Sep 30, 2026.
How has the price of ESTRADIOL 0.1% (0.25 MG) GEL PK changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.1% (0.25 MG) GEL PK has declined 77.8%. It has been tracked across 155 weekly CMS publications since Oct 18, 2023.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.1% (0.25 MG) GEL PK?
Since Oct 18, 2023, the NADAC for ESTRADIOL 0.1% (0.25 MG) GEL PK has ranged from a low of $0.7570 (Sep 23, 2026) to a high of $3.7861 (Apr 10, 2024), with a median of $1.7501 per EA.
Are there cheaper alternatives to ESTRADIOL 0.1% (0.25 MG) GEL PK?
3 manufacturers publish a NADAC-priced product with the same active ingredient and strength as ESTRADIOL 0.1% (0.25 MG) GEL PK in a comparable dosage form, but none are currently priced below it.
Who manufactures ESTRADIOL 0.1% (0.25 MG) GEL PK?
ESTRADIOL 0.1% (0.25 MG) GEL PK (NDC 13811009032) is labeled by Trigen Laboratories, LLC, and CMS classifies it as a generic product.