Product Information
ESTRADIOL 0.1% (0.25 MG) GEL PK is a generic product labeled by Encube Ethicals, Inc., priced at $1.3810 per EA under NDC 21922008652. Its NADAC has been published 30 times since Dec 3, 2025.
Strength
.25 mg/.25g
Manufacturer
Encube Ethicals, Inc.NDC
21922008652
Classification
Generic
Dosage Form
GEL
Route
TOPICAL
Last Updated
6/17/2026
Active Ingredients
ESTRADIOLApproval Type
Generic (ANDA)
FDA Application
ANDA218507On Market Since
3/10/2025
Pharmacological Classes
Price Statistics
The NADAC for ESTRADIOL 0.1% (0.25 MG) GEL PK has been published 30 times since Dec 3, 2025, and over the history we have for it it has declined 19.3%. The table below summarizes its recorded NADAC range and movement.
| Current price | $1.3810 per EA |
|---|---|
| All-time high | $1.7226 (Feb 11, 2026) |
| All-time low | $1.3810 (Jun 17, 2026) |
| 52-week high | $1.7226 |
| 52-week low | $1.3810 |
| Median price | $1.5633 |
| Average price | $1.5821 |
| Largest weekly change | -6.9% (Jun 17, 2026) |
| Weeks tracked | 30 |
| Tracking since | Dec 3, 2025 |
Generic Alternatives
The matcher finds 3 NADAC-published products sharing this drug's active ingredient, strength, and dosage form across 3 manufacturers (up to 10 shown below). None of the shown alternatives sit below the current price. These are candidates to verify clinically, not guaranteed substitutes — see our generic drug prices guide.
Frequently asked questions
What is the NADAC price of ESTRADIOL 0.1% (0.25 MG) GEL PK?
The current National Average Drug Acquisition Cost (NADAC) for ESTRADIOL 0.1% (0.25 MG) GEL PK, manufactured by Encube Ethicals, Inc., is $1.3810 per EA (NDC 21922008652), effective Jun 24, 2026.
How has the price of ESTRADIOL 0.1% (0.25 MG) GEL PK changed over time?
Over the history we have for it, the NADAC for ESTRADIOL 0.1% (0.25 MG) GEL PK has declined 19.3%. It has been tracked across 30 weekly CMS publications since Dec 3, 2025.
What are the highest and lowest recorded NADAC prices for ESTRADIOL 0.1% (0.25 MG) GEL PK?
Since Dec 3, 2025, the NADAC for ESTRADIOL 0.1% (0.25 MG) GEL PK has ranged from a low of $1.3810 (Jun 17, 2026) to a high of $1.7226 (Feb 11, 2026), with a median of $1.5633 per EA.
Are there cheaper alternatives to ESTRADIOL 0.1% (0.25 MG) GEL PK?
3 NADAC-published products share the same active ingredient, strength, and dosage form as ESTRADIOL 0.1% (0.25 MG) GEL PK, but none are currently priced below it.
Who manufactures ESTRADIOL 0.1% (0.25 MG) GEL PK?
ESTRADIOL 0.1% (0.25 MG) GEL PK (NDC 21922008652) is labeled by Encube Ethicals, Inc., and CMS classifies it as a generic product.
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